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文莱达鲁萨兰国所产植物的化学成分含量及抗氧化、抗糖尿病和伤口愈合活性的研究。

An Investigation into the Phytochemical Content and Antioxidant, Antidiabetic, and Wound-Healing Activities of Found in Brunei Darussalam.

机构信息

Chemical Sciences Faculty of Science Universiti Brunei Darussalam, Jalan Tungku Link, Gadong BE1410, Brunei Darussalam.

Osaka University ASEAN Campus Brunei Darussalam, No. 13, Kg Mabohai, Bandar Seri Begawan BA1111, Brunei Darussalam.

出版信息

ScientificWorldJournal. 2024 Aug 3;2024:5656744. doi: 10.1155/2024/5656744. eCollection 2024.

DOI:10.1155/2024/5656744
PMID:39130077
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11316913/
Abstract

This present study aimed to investigate the phytochemical content and antioxidant and antidiabetic activities of leaves (CL) and roots (CR) found in Brunei Darussalam. Phytochemical screening showed that CL and CR extracts contain saponins, tannins, glycosides, and terpenoids. CR showed higher total phenolic content (TPC), but lower total flavonoid content (TFC) when compared to CL. The high TPC in CR contributed to its potent radical scavenging activity (RSA) against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals and strong ferric reducing antioxidant power (FRAP). Additionally, CR exerted significant inhibition of ∝-glucosidase and ∝-amylase, suggesting a potential link between the chemical compounds and its antioxidant and antidiabetic effects. In the animal study of antihyperglycemic activity, treatment with 250 mg/kg body weight (b.w.) of the CL extract normalised the blood glucose levels and improved body weight gain of alloxan-induced diabetic rats within 14 weeks. Furthermore, our investigation into the wound-healing effects of young leaves (YCL) and matured leaves (MCL) showed a significant reduction in wound size on Day 3, 5, and 7 of the experimental study, indicating its wound-healing potential. Based on our findings, can be consumed as part of a balanced diet due to its antioxidant and antidiabetic properties.

摘要

本研究旨在探究文莱发现的 叶子（CL）和 根（CR）的植物化学物质含量、抗氧化和抗糖尿病活性。植物化学筛选表明，CL 和 CR 提取物含有皂甙、单宁、糖苷和萜类化合物。与 CL 相比，CR 表现出更高的总酚含量（TPC），但总黄酮含量（TFC）较低。CR 中的高 TPC 使其具有强大的 2,2-二苯基-1-苦基肼（DPPH）自由基清除活性（RSA）和强铁还原抗氧化能力（FRAP）。此外，CR 对 α-葡萄糖苷酶和 α-淀粉酶有显著抑制作用，表明化合物与其抗氧化和抗糖尿病作用之间存在潜在联系。在抗高血糖活性的动物研究中，250mg/kg 体重（b.w.）CL 提取物的治疗使四氧嘧啶诱导的糖尿病大鼠的血糖水平正常化，并在 14 周内改善体重增加。此外，我们对幼叶（YCL）和成熟叶（MCL）的伤口愈合作用的研究表明，在实验研究的第 3、5 和 7 天，伤口大小显著减小，表明其具有伤口愈合潜力。根据我们的发现，由于其抗氧化和抗糖尿病特性，可作为均衡饮食的一部分进行消费。

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