Freeman P, Salamonsen R F, Mainland J F
Arch Otolaryngol. 1985 Feb;111(2):75-8. doi: 10.1001/archotol.1985.00800040039002.
A laboratory study in 11 healthy subjects was conducted to evaluate the performance of a rebreathing device as a means of raising the effective carbon dioxide level in the inspiratory mixture. In all subjects, there was a sustained rise in end-tidal carbon dioxide levels and a transient rise in end-tidal nitrogen tensions associated with an equivalent fall in end-tidal oxygen levels. Although the rise in end-tidal carbon dioxide tensions was variable, the mean elevation for the 11 subjects (from 36 to 43 mm Hg) was not equivalent to elevations reported to follow inhalation of 5% carbon dioxide mixtures. Nevertheless, the volume of the device was sufficient to cause a marked depression of the end-tidal oxygen level (to 67 mm Hg) in one subject. Despite the simplicity and cost-effectiveness of the rebreathing method, it cannot be recommended in the treatment of sudden or fluctuant sensorineural deafness.
对11名健康受试者进行了一项实验室研究，以评估一种重复呼吸装置作为提高吸气混合物中有效二氧化碳水平的手段的性能。在所有受试者中，呼气末二氧化碳水平持续升高，呼气末氮分压短暂升高，同时呼气末氧水平相应下降。尽管呼气末二氧化碳分压的升高存在差异，但11名受试者的平均升高幅度（从36毫米汞柱升至43毫米汞柱）与吸入5%二氧化碳混合物后报告的升高幅度并不相同。然而，该装置的容量足以使一名受试者的呼气末氧水平显著降低（降至67毫米汞柱）。尽管重复呼吸方法简单且具有成本效益，但在突发性或波动性感音神经性耳聋的治疗中不推荐使用。
