Department of Medical Cardiology, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang 330006, China; Clinical Medical College, Jiangxi University of Chinese Medicine, Nanchang 330006, China.
Graduate School, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Biomed Pharmacother. 2024 Oct;179:117319. doi: 10.1016/j.biopha.2024.117319. Epub 2024 Aug 27.
Metabolic diseases (MetD) such as diabetes mellitus, obesity, and hyperlipidemia have become global health challenges. As a naturally occurring plant component, puerarin has been verified to possess a wide range of pharmacological effects including lowering blood glucose, improving insulin resistance, and regulating lipid metabolism, which has attracted extensive attention in recent years, and its potential in the treatment of MetD has been highly acclaimed. In addition, puerarin has exhibited antioxidant, anti-inflammatory, and cardiovascular protective effects, which are of great significance in the prevention and treatment of MetD. This article comprehensively summarizes the research progress of puerarin in the treatment of MetD and explores its pharmacological mechanisms, clinical applications, and future perspectives. More importantly, this review provided a list of the involved molecular mechanims in treating MetD of puerarin. Taking into account these conclusions, it may provide a strong foundation for the optimized use of puerarin in the treatment of patients suffering from MetD.
代谢性疾病（MetD）如糖尿病、肥胖症和高血脂症已成为全球健康挑战。作为一种天然存在的植物成分，葛根素已被证实具有广泛的药理作用，包括降低血糖、改善胰岛素抵抗和调节脂代谢，近年来引起了广泛关注，其在代谢性疾病治疗中的潜力备受赞誉。此外，葛根素还具有抗氧化、抗炎和心血管保护作用，对代谢性疾病的预防和治疗具有重要意义。本文全面总结了葛根素在治疗代谢性疾病方面的研究进展，探讨了其药理机制、临床应用及未来展望。更重要的是，本文综述了葛根素治疗代谢性疾病的相关分子机制，为优化葛根素在代谢性疾病患者治疗中的应用提供了有力依据。综上所述，这可能为优化葛根素在治疗代谢性疾病患者中的应用提供了有力依据。
