Affiliated Hospital of Jiangxi University of Chinese Medicine, 445 Bayi Avenue, Nanchang, 330006, China.
Clinical Medical College, Jiangxi University of Chinese Medicine, 445 Bayi Avenue, Nanchang, 330006, China.
Naunyn Schmiedebergs Arch Pharmacol. 2024 Oct;397(10):7273-7296. doi: 10.1007/s00210-024-03142-3. Epub 2024 May 6.
Cardiovascular diseases (CVDs) are the leading causes of death globally that seriously threaten human health. Although novel western medicines have continued to be discovered over the past few decades to inhibit the progression of CVDs, new drug research and development for treating CVDs with less side effects and adverse reactions are continuously being desired. Puerarin is a natural product found in a variety of medicinal plants belonging to the flavonoid family with potent biological and pharmacological activities. Abundant research findings in the literature have suggested that puerarin possesses a promising prospect in treating CVDs. In recent years, numerous new molecular mechanisms of puerarin have been explored in experimental and clinical studies, providing new evidence for this plant metabolite to protect against CVDs. This article systematically introduces the history of use, bioavailability, and various dosage forms of puerarin and further summarizes recently published data on the major research advances and their underlying therapeutic mechanisms in treating CVDs. It may provide references for researchers in the fields of pharmacology, natural products, and internal medicine.
心血管疾病（CVDs）是全球主要的致死原因，严重威胁人类健康。尽管在过去几十年中不断发现新的西药来抑制 CVDs 的进展，但人们仍在不断寻求具有更少副作用和不良反应的治疗 CVDs 的新药研发。葛根素是一种天然产物，存在于多种属于黄酮类的药用植物中，具有强大的生物学和药理学活性。大量文献研究结果表明，葛根素在治疗 CVDs 方面具有广阔的前景。近年来，实验和临床研究探索了葛根素的许多新的分子机制，为这种植物代谢物预防 CVDs 提供了新的证据。本文系统地介绍了葛根素的使用历史、生物利用度和各种剂型，并进一步总结了最近发表的关于治疗 CVDs 的主要研究进展及其潜在治疗机制的数据。它可能为药理学、天然产物和内科等领域的研究人员提供参考。
