Wilson J A, Craig I F
Br Med J (Clin Res Ed). 1985 Mar 16;290(6471):807-8. doi: 10.1136/bmj.290.6471.807.
To assess the effect of cimetidine and ranitidine on high density lipoprotein (HDL) cholesterol concentration two groups of eight patients with duodenal ulcer or oesophagitis matched for age, sex, and cigarette consumption were given either cimetidine 1 g daily or ranitidine 300 mg daily for one month. There was no significant change in the cholesterol content of HDL and its subfraction HDL3 after treatment with ranitidine or cimetidine, or in the cholesterol content of the subfraction HDL2 after treatment with ranitidine; the HDL2 cholesterol concentration was, however, significantly increased after treatment with cimetidine. Further studies are being undertaken to establish the mechanism of this effect.
为评估西咪替丁和雷尼替丁对高密度脂蛋白（HDL）胆固醇浓度的影响，将两组各8例年龄、性别及吸烟量匹配的十二指肠溃疡或食管炎患者，分别给予每日1克西咪替丁或每日300毫克雷尼替丁，治疗1个月。服用雷尼替丁或西咪替丁后，HDL的胆固醇含量及其亚组分HDL3无显著变化；服用雷尼替丁后，HDL2亚组分的胆固醇含量也无显著变化；然而，服用西咪替丁后，HDL2胆固醇浓度显著升高。正在进行进一步研究以确定这种作用的机制。
