Grainger S L, Nanjee M N, Thompson R P, Miller N E
Gastrointestinal Laboratory, Rayne Institute, St Thomas' Hospital, London, UK.
Pharmacology. 1988;36(6):420-6. doi: 10.1159/000138331.
The effects of cimetidine (400 mg b.d.) and ranitidine (150 mg b.d.) on high-density lipoprotein (HDL) subclasses and other plasma lipoproteins were studied in 18 men and 15 women with reflux oesophagitis and/or duodenitis. Serum testosterone and sex hormone binding globulin (SHBG) concentrations were also measured. Treatment with either drug was continued for 12 weeks. Ranitidine had no significant effect on any measured variable in either men or women. Cimetidine had no effect in men, but in women it raised the cholesterol concentration in the HDL2 subclass by 15% after 8 weeks, and by 48% after 12 weeks. In females, cimetidine also reduced the concentrations of SHBG (by 24% at 12 weeks) and of total testosterone (by 25% at 12 weeks). The significance of these latter changes is uncertain, however, as estimates of the biologically active free testosterone concentration were unchanged.
在18名男性和15名患有反流性食管炎和/或十二指肠炎症的女性中，研究了西咪替丁（每日两次，每次400毫克）和雷尼替丁（每日两次，每次150毫克）对高密度脂蛋白（HDL）亚类及其他血浆脂蛋白的影响。同时也测定了血清睾酮和性激素结合球蛋白（SHBG）的浓度。两种药物的治疗均持续12周。雷尼替丁对男性或女性的任何测量变量均无显著影响。西咪替丁对男性没有作用，但对女性而言，8周后HDL2亚类中的胆固醇浓度升高了15%，12周后升高了48%。在女性中，西咪替丁还降低了SHBG的浓度（12周时降低24%）和总睾酮的浓度（12周时降低25%）。然而，由于生物活性游离睾酮浓度的估计值未变，后述这些变化的意义尚不确定。
