Department of Biomedicine, Aarhus University, Aarhus, Denmark; Center for Immunology of Viral Infections, Aarhus, Denmark.
Department of Biomedicine, Aarhus University, Aarhus, Denmark; Center for Immunology of Viral Infections, Aarhus, Denmark.
Trends Immunol. 2024 Sep;45(9):662-677. doi: 10.1016/j.it.2024.07.010. Epub 2024 Aug 27.
Herpesviruses are DNA viruses and the cause of diseases ranging from mild skin conditions to severe brain diseases. Mammalian antiviral host defense comprises an array of mechanisms, including restriction factors (RFs), which block specific steps in viral replication cycles. In recent years, knowledge of RFs that contribute to controlling herpesvirus infections has expanded significantly, along with a new understanding of viral evasion mechanisms and disease pathogenesis. By integrating findings from human genetics, murine models, and cellular studies, this review provides a current view of RF control of herpesvirus infections. We also explore the regulation of RF expression, discuss the roles of RFs in diseases, and point towards their growing potential as candidate therapeutic targets.
疱疹病毒是 DNA 病毒，可引起从轻度皮肤疾病到严重脑部疾病等多种疾病。哺乳动物抗病毒宿主防御包括一系列机制，包括限制因子（RFs），它们阻断病毒复制周期中的特定步骤。近年来，有助于控制疱疹病毒感染的 RF 知识得到了极大的扩展，同时也对病毒逃逸机制和疾病发病机制有了新的认识。本综述通过整合人类遗传学、鼠模型和细胞研究的发现，提供了 RF 控制疱疹病毒感染的最新观点。我们还探讨了 RF 表达的调节，讨论了 RF 在疾病中的作用，并指出它们作为候选治疗靶点的潜力日益增加。
