Department of Neurology, Faculty of Medicine, Oita University, Japan.
Department of Otolaryngology-Head and Neck Surgery, Oita University, Japan.
Intern Med. 2024 Nov 1;63(21):2983-2986. doi: 10.2169/internalmedicine.4110-24. Epub 2024 Aug 28.
Multiple system atrophy (MSA) is a progressive neurodegenerative disease that often causes vocal cord paralysis (VCP), Parkinsonism, cerebellar ataxia, and autonomic dysfunction. VCP is the most fatal symptom that affects the prognosis of patients with MSA. Coronavirus disease 2019 (COVID-19) is often associated with neurological complications and it has recently been reported to induce VCP in patients without neurodegenerative diseases. We herein present two cases of patients with MSA in whom VCP worsened after COVID-19 and this led to the need to perform emergency tracheostomies. As VCP may deteriorate after COVID-19 in patients with MSA, it is important to prevent COVID-19 in these patients and closely monitor such patients for any signs of VCP deterioration post-infection to improve their prognosis.
多系统萎缩（MSA）是一种进行性神经退行性疾病，常导致声带麻痹（VCP）、帕金森病、小脑共济失调和自主神经功能障碍。VCP 是最致命的症状，影响 MSA 患者的预后。2019 年冠状病毒病（COVID-19）常伴有神经系统并发症，最近有报道称，它可在无神经退行性疾病的患者中引起 VCP。我们在此介绍两例 MSA 患者，他们在感染 COVID-19 后 VCP 恶化，需要进行紧急气管切开术。由于 MSA 患者在感染 COVID-19 后 VCP 可能恶化，因此对这些患者进行 COVID-19 预防并密切监测感染后 VCP 恶化的任何迹象，以改善其预后非常重要。
