新生儿呼出气体中的挥发性有机化合物：一项初步研究。
Volatile organic compounds in exhaled breath of newborns: a pilot study.
作者信息
Farghaly Mohsen A A, Abuelazm Somaya, Elgendy Marwa M, Grove David, Abu-Shaweesh Jalal M, Dweik Raed A, Aly Hany
机构信息
Neonatology Division, Cleveland Clinic Children's Hospital, Cleveland, OH, USA.
Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA.
出版信息
J Perinatol. 2025 Apr;45(4):450-453. doi: 10.1038/s41372-024-02102-2. Epub 2024 Aug 28.
OBJECTIVE
To assess volatile organic compounds (VOCs) in breath samples collected non-invasively from preterm and full-term infants.
METHODS
This was a pilot study included preterm and full-term infants who were not intubated or suspected or diagnosed with metabolic or gastrointestinal disorders. The samples were analyzed for VOCs using a selected-ion flow-tube mass spectrometer.
RESULTS
Twenty infants were included; ten preterm and ten full-term infants. Twenty-two VOCs were detected and measurable in all samples. There was a significant difference between preterm and full-term infants for the 2-propanol, acetaldehyde, acetone, acetonitrile, benzene, ethanol, isoprene, pentane, 3-methylhexane, 2-nonene, ethane, triethylamine, and trimethylamine compounds.
CONCLUSION
It is feasible to measure VOCs in breath samples of preterm and full-term non-intubated infants. Full-term infants express different concentrations than preterm infants. Further studies are needed to examine the utility and reproducibility of measuring VOCs to identify neonatal diseases and predict outcomes.
目的
评估从早产儿和足月儿非侵入性采集的呼吸样本中的挥发性有机化合物（VOCs）。
方法
这是一项试点研究，纳入了未插管、未怀疑或诊断患有代谢或胃肠道疾病的早产儿和足月儿。使用选择离子流管质谱仪对样本进行VOCs分析。
结果
共纳入20名婴儿，其中10名早产儿和10名足月儿。在所有样本中检测并可测量出22种VOCs。早产儿和足月儿在2-丙醇、乙醛、丙酮、乙腈、苯、乙醇、异戊二烯、戊烷、3-甲基己烷、2-壬烯、乙烷、三乙胺和三甲胺化合物方面存在显著差异。
结论
测量未插管的早产儿和足月儿呼吸样本中的VOCs是可行的。足月儿与早产儿表现出不同的浓度。需要进一步研究以检验测量VOCs用于识别新生儿疾病和预测预后的效用及可重复性。
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