Regional Neonatal Intensive Care Unit, University Hospital of Wales, Cardiff, United Kingdom.
Department of Child Health, School of Medicine, Cardiff University, Cardiff, United Kingdom.
J Breath Res. 2021 Feb 25;15(2). doi: 10.1088/1752-7163/abe283.
Volatile organic compounds (VOCs) detected in human breath, urine, stool, sweat, saliva, and blood result from metabolic processes in the body during health or disease. Using sophisticated measurement systems, small amounts of these compounds can be detected in the above bodily fluids. Multiple studies in adults and children have shown the potential of these compounds to differentiate between healthy individuals and patients by detecting profiles of compounds in non-invasively collected samples. However, the detection of biomarkers in VOCs from neonates is particularly attractive due to the non-invasive nature of its approach, and its ability to track disease progress by longitudinal sampling. In this work we have reviewed the literature on the use of VOCs in neonates and identified areas for future work. Overview of VOCs and their usefulness as metabolic signatures. Detailed review of studies on VOCs in neonates Learn about potential uses of VOCs as derived from adult and paediatric studies. Examine current limitations and identify future work. Detailed studies on VOCs involving neonatal patients including sick preterm infants and term infants with specific morbidities are needed. These studies should collect longitudinal samples using non-invasive methods for the detection of potential biomarkers. Underlying metabolic processes need to be identified so that any therapeutic options can be clarified.
人体呼吸、尿液、粪便、汗液、唾液和血液中检测到的挥发性有机化合物（VOCs）源自健康或疾病状态下体内的代谢过程。使用复杂的测量系统，可以从上述体液中检测到这些化合物的少量存在。多项针对成人和儿童的研究表明，通过检测非侵入性采集样本中的化合物谱，可以利用这些化合物来区分健康个体和患者。然而，由于其方法具有非侵入性，并且能够通过纵向采样跟踪疾病进展，因此从新生儿的 VOC 中检测生物标志物特别具有吸引力。在这项工作中，我们回顾了有关新生儿中 VOC 应用的文献，并确定了未来的工作方向。VOC 的概述及其作为代谢特征的有用性。详细回顾了关于新生儿 VOC 的研究。了解从成人和儿科研究中得出的 VOC 的潜在用途。检查当前的限制并确定未来的工作。需要对涉及新生儿患者的 VOC 进行详细研究，包括患有特定疾病的早产儿和足月婴儿。这些研究应使用非侵入性方法采集纵向样本，以检测潜在的生物标志物。需要确定潜在的代谢过程，以便阐明任何治疗选择。
