Shandong Electric Power Center Hospital, Jinan, China.
State Key Laboratory for Innovation and Transformation of Luobing Theory; Key Laboratory of Cardiovascular Remodeling and Function Research, Department of Cardiology, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, Qilu Hospital of Shandong University, Jinan, China.
Sci Rep. 2024 Aug 29;14(1):20038. doi: 10.1038/s41598-024-70213-z.
Triglyceride-Glucose Index (TyG index) and HbA1c are metabolic risk factors associated with insulin resistance (IR), which have been confirmed to be independently correlated with the incidence of hypertension. However, there is limited research specifically focusing on the interaction between these two metabolic risk factors in hypertensive populations. Currently, it remains unclear how the metabolic indicators TyG index and HbA1c affect BP control in individuals with hypertension. This study aims to investigate the value and interaction of TyG index and HbA1c in blood pressure (BP) control among hypertensive patients. The results are conducive to enhancing the effectiveness of clinical BP control for individuals with hypertension. This cohort study included 99,336 adults diagnosed with hypertension. Participants were grouped according to the median of TyG index and HbA1c. The main endpoint is inadequate BP control. Multivariable-adjusted risk ratios and multivariable Cox regression analysis were used to represent the relationship between BP control levels and metabolic risk factors. Finally, we evaluated the interaction between TyG index and HbA1c in the population with inadequate BP control. This study confirmed that TyG index and HbA1c, as metabolic risk factors, are independently associated with poor BP control (P < 0.05). In multivariable Cox regression analysis, it was found that TyG index and HbA1c were significantly associated with poor BP control. In the male elderly population, HbA1c was significantly associated with poor BP control (P = 0.029).
甘油三酯-葡萄糖指数（TyG 指数）和糖化血红蛋白（HbA1c）是与胰岛素抵抗（IR）相关的代谢风险因素，已被证实与高血压的发生独立相关。然而，目前针对高血压人群中这两种代谢风险因素之间相互作用的研究有限。目前尚不清楚代谢指标 TyG 指数和 HbA1c 如何影响高血压患者的血压控制。本研究旨在探讨 TyG 指数和 HbA1c 在高血压患者血压控制中的价值和相互作用。研究结果有助于提高高血压患者临床血压控制的效果。本队列研究纳入了 99336 名诊断为高血压的成年人。根据 TyG 指数和 HbA1c 的中位数将参与者进行分组。主要终点是血压控制不充分。使用多变量调整风险比和多变量 Cox 回归分析来表示血压控制水平与代谢风险因素之间的关系。最后，我们评估了 TyG 指数和 HbA1c 在血压控制不充分人群中的相互作用。本研究证实，TyG 指数和 HbA1c 作为代谢风险因素，与血压控制不佳独立相关（P<0.05）。在多变量 Cox 回归分析中，发现 TyG 指数和 HbA1c 与血压控制不佳显著相关。在男性老年人群中，HbA1c 与血压控制不佳显著相关（P=0.029）。
