Faculty of Medicine, Gadarif University, Gadarif, Sudan.
Department of Medicine, Royal Commission Hospital in Al Jubail Industrial City, Al Jubail, Kingdom of Saudi Arabia.
BMC Cardiovasc Disord. 2022 May 10;22(1):208. doi: 10.1186/s12872-022-02649-y.
Glycosylated haemoglobin (HbA1c) is considered reliable for diagnosing and monitoring diabetes mellitus (DM). It also indicates cardiovascular complications related to DM. However, only a few studies have been conducted on this topic.
We conducted a cross-sectional study to investigate the association between newly diagnosed hypertension and HbA1c among non-diabetic Sudanese adults. The sociodemographic characteristics of the participants in the sample were gathered using a questionnaire, and HbA1c was measured using an Ichroma machine.
Three hundred and eighty-four healthy participants were enrolled in this study. The median (interquartile range [IQR]) age was 56.0 (14.0) years, and 72.1% of the participants were female. The median (IQR) body mass index (BMI) was 31.2 (8.7) kg/m. One hundred and fifteen (29.9%) participants presented newly diagnosed hypertension. The results of the multivariate analysis showed that age (adjusted odd ratio [AOR] = 1.03; 95% confidence interval [CI] = 1.01‒1.05); BMI (AOR = 1.09; 95% CI = 1.05‒1.14); HbA1c levels (AOR = 2.18; 95% CI = 1.29‒3.67) was positively associated with newly diagnosed hypertension. For an HbA1c level of 5.0% or more, the sensitivity and specificity of newly diagnosed hypertension were 91.3% and 28.2%, respectively (area under the curve = 0.61; 95% CI = 0.55-0.67; P ˂ 0.001). Participants who presented HbA1c levels of 5.0% or more were found to be at higher risk for newly diagnosed hypertension (AOR = 2.53; 95% CI = 1.14‒5.61).
The results of this study indicated a high prevalence of newly diagnosed hypertension, and HbA1c levels were positively associated with newly diagnosed hypertension.
糖化血红蛋白（HbA1c）被认为是诊断和监测糖尿病（DM）的可靠指标，它还能指示与 DM 相关的心血管并发症。然而，针对这一主题的研究很少。
我们进行了一项横断面研究，以调查非糖尿病苏丹成年人中新诊断出的高血压与 HbA1c 之间的关系。使用问卷收集样本中参与者的社会人口统计学特征，并使用 Ichroma 机器测量 HbA1c。
本研究纳入了 384 名健康参与者。年龄中位数（四分位距 [IQR]）为 56.0（14.0）岁，72.1%的参与者为女性。体重指数（BMI）中位数（IQR）为 31.2（8.7）kg/m2。115 名（29.9%）参与者患有新诊断的高血压。多变量分析结果显示，年龄（调整后的优势比 [AOR] = 1.03；95%置信区间 [CI] = 1.01-1.05）；BMI（AOR = 1.09；95% CI = 1.05-1.14）；HbA1c 水平（AOR = 2.18；95% CI = 1.29-3.67）与新诊断的高血压呈正相关。对于 HbA1c 水平为 5.0%或更高，新诊断高血压的敏感性和特异性分别为 91.3%和 28.2%（曲线下面积 [AUC] = 0.61；95% CI = 0.55-0.67；P ˂ 0.001）。发现 HbA1c 水平为 5.0%或更高的参与者发生新诊断高血压的风险更高（AOR = 2.53；95% CI = 1.14-5.61）。
本研究结果表明新诊断高血压的患病率较高，HbA1c 水平与新诊断高血压呈正相关。
