Division of Nephrology, Peking University Third Hospital, Beijing, 100191, China.
Department of Nephrology, Xuzhou First People's Hospital, Xuzhou, 221000, Jiangsu, China.
BMC Nephrol. 2024 Aug 28;25(1):278. doi: 10.1186/s12882-024-03697-6.
There were limited data investigating platelet indices in predicting peritoneal dialysis (PD) outcomes on comorbidities. The aim of this study was to evaluate the association between platelet indices and new-onset comorbidity and all-cause mortality in PD patients.
A single-center, retrospective observational cohort study was conducted in incident PD patients from 28 December 2011 to 24 January 2018, and followed up until 31 December 2022. Time to the first new-onset cardiovascular disease (CVD) and time to the first new-onset infection event after PD were identified as the primary outcomes. All-cause mortality was identified as the secondary endpoint. The correlation between platelet indices and comorbidities and all-cause mortality were assessed by Cox model. Data of liver disease status was not collected and analyzed. Survival curves were performed by Kaplan-Meier method with log-rank tests.
A total of 250 incident PD patients with a median follow-up of 6.79 (inter-quarter range 4.05, 8.89) years was included. A total of 81 and 139 patients experienced the first new-onset CVD and infection event respectively during the follow-up period. High mean platelet volume (MPV) was independently associated with high risk of time to the first new-onset CVD (HR 1.895, 95% CI 1.174-3.058, p = 0.009) and all-cause mortality (HR 1.710, 95% CI 1.155-2.531, p = 0.007). Patients with low mean platelet volume to platelet count ratio (MPV/PC) were prone to occur the new-onset infection events (log rank 5.693, p = 0.017). Low MPV/PC (HR 0.652, 95% CI 0.459-0.924, p = 0.016) was significantly associated with the time to the first new-onset infection event on PD.
Platelet indices were associated with the new-onset CVD, infectious comorbidities and all-cause mortality on PD. Low MPV/PC was associated with time to the first new-onset infection event in PD patients. Moreover, high MPV was associated with new-onset CVD and all-cause mortality in the incident PD patients.
关于血小板指数在预测合并症的腹膜透析（PD）结局方面的研究数据有限。本研究旨在评估血小板指数与 PD 患者新发合并症和全因死亡率之间的关系。
这是一项单中心、回顾性观察性队列研究，纳入了 2011 年 12 月 28 日至 2018 年 1 月 24 日期间新发生的 PD 患者，并随访至 2022 年 12 月 31 日。首次新发心血管疾病（CVD）和 PD 后首次新发感染事件的时间被确定为主要结局。全因死亡率被确定为次要终点。采用 Cox 模型评估血小板指数与合并症和全因死亡率之间的相关性。未收集和分析肝病状态的数据。生存曲线采用 Kaplan-Meier 方法和对数秩检验进行分析。
共纳入 250 例新发生的 PD 患者，中位随访时间为 6.79 年（四分位距 4.05-8.89 年）。在随访期间，共有 81 例和 139 例患者分别发生了首次新发 CVD 和感染事件。高平均血小板体积（MPV）与首次新发 CVD 的时间（HR 1.895，95%CI 1.174-3.058，p=0.009）和全因死亡率（HR 1.710，95%CI 1.155-2.531，p=0.007）的高风险独立相关。平均血小板体积与血小板计数比值（MPV/PC）低的患者易发生新发感染事件（对数秩检验 5.693，p=0.017）。低 MPV/PC（HR 0.652，95%CI 0.459-0.924，p=0.016）与 PD 患者首次新发感染事件的时间显著相关。
血小板指数与 PD 患者的新发 CVD、感染性合并症和全因死亡率相关。低 MPV/PC 与 PD 患者首次新发感染事件的时间相关。此外，高 MPV 与新发 CVD 和 PD 患者的全因死亡率相关。
