Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Department of Hematology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Ren Fail. 2022 Dec;44(1):1640-1648. doi: 10.1080/0886022X.2022.2130802.
The global mortality rate from chronic kidney disease (CKD) has increased over the past two decades. Typically, peritoneal dialysis (PD) remains a useful alternative treatment for end-stage renal disease. Cardiovascular disease (CVD) is the main complication in PD patients. In terms of prognosis, it is reported that platelet distribution width (PDW) can predict adverse CVD events. However, the relationship between PDW and new-onset CVD in PD patients is not clear. This study aimed to explore the relationship between PDW and new-onset CVD in PD patients.
This was a retrospective cohort study, from 4 July 2005 to 31 December 2019, and a total of 1557 patients were recruited. PDW was respectively categorized into two groups: PDW ≤13.2 fL and PDW >13.2 fL. The primary outcome was a new-onset CVD event. Cox proportional hazards models were performed to assess the hazard ratio (HR). Receiver-operating characteristic (ROC) curves were applied to evaluate the predictive accuracy of the PDW on CVD events.
During follow-up, 114 new-onset CVD events were recorded. Cox proportional hazards models showed a higher risk of CVD events in patients with high PDW (HR = 1.862 95%CI 1.205-2.877, = 0.005). Kaplan-Meier cumulative incidence curves showed the risk of the first occurrence of CVD events was greater in the high PDW group ( = 0.006).
High PDW is associated with new-onset cardiovascular disease events in PD patients.
在过去的二十年中，慢性肾脏病（CKD）的全球死亡率有所增加。通常，腹膜透析（PD）仍然是终末期肾脏疾病的一种有用的替代治疗方法。心血管疾病（CVD）是 PD 患者的主要并发症。就预后而言，据报道血小板分布宽度（PDW）可预测不良 CVD 事件。然而，PDW 与 PD 患者新发 CVD 之间的关系尚不清楚。本研究旨在探讨 PDW 与 PD 患者新发 CVD 之间的关系。
这是一项回顾性队列研究，时间为 2005 年 7 月 4 日至 2019 年 12 月 31 日，共纳入 1557 名患者。PDW 分别分为两组：PDW ≤13.2fl 和 PDW >13.2fl。主要结局是新发 CVD 事件。使用 Cox 比例风险模型评估风险比（HR）。应用受试者工作特征（ROC）曲线评估 PDW 对 CVD 事件的预测准确性。
在随访期间，记录到 114 例新发 CVD 事件。Cox 比例风险模型显示，PDW 较高的患者发生 CVD 事件的风险更高（HR=1.862，95%CI 1.205-2.877， =0.005）。Kaplan-Meier 累积发病率曲线显示，PDW 较高组发生 CVD 事件的风险更大（ =0.006）。
PDW 升高与 PD 患者新发心血管疾病事件相关。
