Wang Meiyao, Zhou Jun, Xu Gangchun, Tang Yongkai
Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China.
Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture and Rural Affairs, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, China.
Antioxidants (Basel). 2024 Aug 14;13(8):986. doi: 10.3390/antiox13080986.
(1) The development and utilization of the vast saline-alkali land worldwide is an important way to solve the worsening food crisis. , due to its strong osmotic regulation capability and its characteristics of being suitable for culturing in alkaline water, has become a potential aquaculture species in saline-alkali water. The brain and heart are the key tissues for signal transduction and energy supply under environmental stress. (2) This study is the first to explore the synergistic regulatory molecular mechanism by integrated analysis on cerebral ganglion proteomics and heart metabolomics of under alkalinity stress. (3) The results indicate that the cerebral ganglion and heart of were closely related in response to acute alkalinity stress. The differential regulatory pathways mainly involved regulation of energy metabolism, amino acid metabolism, and homeostasis maintenance. Importantly, alkalinity stress induced the regulation of antioxidants and further adjusted longevity and rhythm in the cerebral ganglion and heart, reflecting that the cerebral ganglion and heart may be the key tissues for the survival of under an alkalinity environment. (4) This study provides a theoretical reference for research on the regulation mechanism of under alkalinity condition and contributes to the development of aquaculture in saline-alkali water.
（1）全球范围内大量盐碱地的开发利用是解决日益严峻的粮食危机的重要途径。由于其强大的渗透调节能力以及适合在碱性水中养殖的特性，已成为盐碱水养殖的潜在物种。脑和心脏是环境胁迫下信号转导和能量供应的关键组织。（2）本研究首次通过对碱性胁迫下[物种名称未给出]脑神经节蛋白质组学和心脏代谢组学的综合分析，探索其协同调控分子机制。（3）结果表明，[物种名称未给出]的脑神经节和心脏在应对急性碱性胁迫时密切相关。差异调控途径主要涉及能量代谢、氨基酸代谢和内稳态维持。重要的是，碱性胁迫诱导了抗氧化剂的调控，并进一步调节了脑神经节和心脏中的寿命和节律，这表明脑神经节和心脏可能是[物种名称未给出]在碱性环境中生存的关键组织。（4）本研究为[物种名称未给出]在碱性条件下的调控机制研究提供了理论参考，有助于盐碱水养殖的发展。
