Division of Cardiology, Departments of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095# Jiefang Ave., Wuhan 430030, China.
Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan 430030, China.
Biomolecules. 2024 Aug 6;14(8):952. doi: 10.3390/biom14080952.
Cardiovascular diseases pose a significant public health challenge globally, necessitating the development of effective treatments to mitigate the risk of cardiovascular diseases. Recently, circular RNAs (circRNAs), a novel class of non-coding RNAs, have been recognized for their role in cardiovascular disease. Aberrant expression of circRNAs is closely linked with changes in various cellular and pathophysiological processes within the cardiovascular system, including metabolism, proliferation, stress response, and cell death. Functionally, circRNAs serve multiple roles, such as acting as a microRNA sponge, providing scaffolds for proteins, and participating in protein translation. Owing to their unique properties, circRNAs may represent a promising biomarker for predicting disease progression and a potential target for cardiovascular drug development. This review comprehensively examines the properties, biogenesis, and potential mechanisms of circRNAs, enhancing understanding of their role in the pathophysiological processes impacting cardiovascular disease. Furthermore, the prospective clinical applications of circRNAs in the diagnosis, prognosis, and treatment of cardiovascular disease are addressed.
心血管疾病在全球范围内构成重大公共卫生挑战，需要开发有效的治疗方法来降低心血管疾病的风险。最近，环状 RNA（circRNA）作为一类新型非编码 RNA，因其在心血管疾病中的作用而受到关注。circRNA 的异常表达与心血管系统内各种细胞和病理生理过程的变化密切相关，包括代谢、增殖、应激反应和细胞死亡。circRNA 具有多种功能，例如充当 microRNA 海绵、为蛋白质提供支架以及参与蛋白质翻译。由于其独特的性质，circRNA 可能成为预测疾病进展的有前途的生物标志物和心血管药物开发的潜在靶点。本综述全面探讨了 circRNA 的特性、生物发生和潜在机制，加深了对其在影响心血管疾病的病理生理过程中作用的理解。此外，还讨论了 circRNA 在心血管疾病诊断、预后和治疗中的临床应用前景。
