College of Basic Medical Science, Institute of Translational Medicine, Key Laboratory of Medical Cell Biology, Ministry of Education, Key Laboratory of Liaoning Province, China Medical University, Shenyang, Liaoning Province, P.R. China, 110122.
Int J Biol Sci. 2021 Jan 1;17(1):89-96. doi: 10.7150/ijbs.52619. eCollection 2021.
The sirtuins family is well known by its unique nicotinamide adenine dinucleotide (NAD)-dependent deacetylase function. The most-investigated member of the family, Sirtuin 1 (SIRT1), accounts for deacetylating a broad range of transcription factors and coregulators, such as p53, the Forkhead box O (FOXO), and so on. It serves as a pivotal regulator in various intracellular biological processes, including energy metabolism, DNA damage response, genome stability maintenance and tumorigenesis. Although the most attention has been focused on its intracellular functions, the regulatory effect on extracellular microenvironment remodeling of SIRT1 has been recognized by researchers recently. SIRT1 can regulate cell secretion process and participate in glucose metabolism, neuroendocrine function, inflammation and tumorigenesis. Here, we review the advances in the understanding of SIRT1 on remodeling the extracellular microenvironment, which may provide new ideas for pathogenesis investigation and guidance for clinical treatment.
去乙酰化酶家族以其独特的烟酰胺腺嘌呤二核苷酸（NAD）依赖性去乙酰化酶功能而闻名。该家族研究最多的成员 Sirtuin 1（SIRT1）负责去乙酰化广泛的转录因子和共调节剂，如 p53、叉头框 O（FOXO）等。它作为各种细胞内生物过程的关键调节剂，包括能量代谢、DNA 损伤反应、基因组稳定性维持和肿瘤发生。尽管人们最关注的是其细胞内功能，但最近研究人员已经认识到 SIRT1 对细胞外微环境重塑的调节作用。SIRT1 可以调节细胞分泌过程，并参与葡萄糖代谢、神经内分泌功能、炎症和肿瘤发生。在这里，我们综述了对 SIRT1 重塑细胞外微环境的理解的进展，这可能为发病机制研究提供新的思路，并为临床治疗提供指导。
