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野生型胶质母细胞瘤远处复发和播散的危险因素：一项单中心研究及荟萃分析

Risk Factors of Distant Recurrence and Dissemination of Wild-Type Glioblastoma: A Single-Center Study and Meta-Analysis.

作者信息

Tsuchiya Takahiro, Kawauchi Daisuke, Ohno Makoto, Miyakita Yasuji, Takahashi Masamichi, Yanagisawa Shunsuke, Osawa Sho, Fujita Shohei, Omura Takaki, Narita Yoshitaka

机构信息

Department of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan.

出版信息

Cancers (Basel). 2024 Aug 18;16(16):2873. doi: 10.3390/cancers16162873.

DOI:10.3390/cancers16162873
PMID:39199644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11352485/
Abstract

Isocitrate dehydrogenase () wild-type glioblastoma (GBM) is a highly aggressive brain tumor with a high recurrence rate despite adjuvant treatment. This study aimed to evaluate the risk factors for non-local recurrence of GBM. In the present study, we analyzed 104 GBMs with a single lesion (non-multifocal or multicentric). Univariate analysis revealed that subventricular zone (SVZ) involvement was significantly associated with non-local recurrence (hazard ratio [HR]: 2.09 [1.08-4.05]). Tumors in contact with the trigone of the lateral ventricle tended to develop subependymal dissemination ( = 0.008). Ventricular opening via surgery did not increase the risk of non-local recurrence in patients with SVZ involvement ( = 0.190). A systematic review was performed to investigate the risk of non-local recurrence, and 21 studies were identified. A meta-analysis of previous studies confirmed SVZ involvement (odds ratio [OR]: 1.30 [1.01-1.67]) and -6-methylguanine DNA methyltransferase promoter methylation (OR: 1.55 [1.09-2.20]) as significant risk factors for local recurrence. A time-dependent meta-analysis revealed a significant association between SVZ involvement and dissemination (HR: 1.69 [1.09-2.63]), while no significant association was found for distant recurrence (HR: 1.29 [0.74-2.27]). Understanding SVZ involvement and specific tumor locations associated with non-local recurrence provides critical insights for the management of GBM.

摘要

异柠檬酸脱氢酶（）野生型胶质母细胞瘤（GBM）是一种侵袭性很强的脑肿瘤，尽管进行了辅助治疗，但其复发率仍很高。本研究旨在评估GBM非局部复发的危险因素。在本研究中，我们分析了104例单发（非多灶性或多中心性）GBM。单因素分析显示，脑室下区（SVZ）受累与非局部复发显著相关（风险比[HR]：2.09[1.08 - 4.05]）。与侧脑室三角区接触的肿瘤易于发生室管膜下播散（ = 0.008）。对于SVZ受累的患者，手术打通脑室并不会增加非局部复发的风险（ = 0.190）。我们进行了一项系统综述以调查非局部复发的风险，并确定了21项研究。对先前研究的荟萃分析证实，SVZ受累（优势比[OR]：1.30[1.01 - 1.67]）和-6-甲基鸟嘌呤DNA甲基转移酶启动子甲基化（OR：1.55[1.09 - 2.20]）是局部复发的重要危险因素。一项时间依赖性荟萃分析显示，SVZ受累与播散之间存在显著关联（HR：1.69[1.09 - 2.63]），而远处复发则未发现显著关联（HR：1.29[0.74 - 2.27]）。了解与非局部复发相关的SVZ受累情况和特定肿瘤位置可为GBM的管理提供关键见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79c7/11352485/5b3af6b0fafb/cancers-16-02873-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79c7/11352485/1cce64c5b727/cancers-16-02873-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79c7/11352485/d3f7c908124d/cancers-16-02873-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79c7/11352485/ba1b24a7f952/cancers-16-02873-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79c7/11352485/8683c9296f25/cancers-16-02873-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79c7/11352485/32785cc91a5c/cancers-16-02873-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79c7/11352485/3d03ac985427/cancers-16-02873-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79c7/11352485/5b3af6b0fafb/cancers-16-02873-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79c7/11352485/1cce64c5b727/cancers-16-02873-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79c7/11352485/d3f7c908124d/cancers-16-02873-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79c7/11352485/ba1b24a7f952/cancers-16-02873-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79c7/11352485/8683c9296f25/cancers-16-02873-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79c7/11352485/32785cc91a5c/cancers-16-02873-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79c7/11352485/3d03ac985427/cancers-16-02873-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79c7/11352485/5b3af6b0fafb/cancers-16-02873-g007.jpg

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J Neurosurg. 2024 Jun 28;141(5):1304-1313. doi: 10.3171/2024.4.JNS232658. Print 2024 Nov 1.
2
The Impact of Lateral Ventricular Opening in the Resection of Newly Diagnosed High-Grade Gliomas: A Single Center Experience.侧脑室开放在新诊断高级别胶质瘤切除术中的影响：单中心经验
Cancers (Basel). 2024 Apr 19;16(8):1574. doi: 10.3390/cancers16081574.
3
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4
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Cells. 2025 Mar 26;14(7):494. doi: 10.3390/cells14070494.
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