Jilin Provincial Key Laboratory of Radiation Oncology and Therapy, Department of Radiation Oncology and Therapy, The First Hospital of Jilin University, Changchun, 130021, China.
Department of Radiation Oncology, Huizhou Third People's Hospital, Guangzhou Medical University, Huizhou, 516000, China.
Stem Cell Res Ther. 2023 May 11;14(1):125. doi: 10.1186/s13287-023-03325-4.
Glioblastoma is one of the most common and aggressive adult brain tumors. The conventional treatment strategy, surgery combined with chemoradiotherapy, did not change the fact that the recurrence rate was high and the survival rate was low. Over the years, accumulating evidence has shown that the subventricular zone has an important role in the recurrence and treatment resistance of glioblastoma. The human adult subventricular zone contains neural stem cells and glioma stem cells that are probably a part of reason for therapy resistance and recurrence of glioblastoma.
Over the years, both bench and bedside evidences strongly support the view that the presence of neural stem cells and glioma stem cells in the subventricular zone may be the crucial factor of recurrence of glioblastoma after conventional therapy. It emphasizes the necessity to explore new therapy strategies with the aim to target subventricular zone to eradicate neural stem cells or glioma stem cells. In this review, we summarize the recent preclinical and clinical advances in targeting neural stem cells in the subventricular zone for glioblastoma treatment, and clarify the prospects and challenges in clinical application.
Although there remain unresolved issues, current advances provide us with a lot of evidence that targeting the neural stem cells and glioma stem cells in subventricular zone may have the potential to solve the dilemma of glioblastoma recurrence and treatment resistance.
胶质母细胞瘤是最常见和侵袭性最强的成人脑肿瘤之一。传统的治疗策略，即手术联合放化疗，并没有改变复发率高、生存率低的事实。多年来，越来越多的证据表明，侧脑室下区在胶质母细胞瘤的复发和治疗耐药中具有重要作用。人类成年侧脑室下区含有神经干细胞和神经胶质瘤干细胞，这可能是治疗耐药和胶质母细胞瘤复发的部分原因。
多年来，无论是在实验室还是临床，都有大量证据强烈支持这样一种观点，即侧脑室下区存在神经干细胞和神经胶质瘤干细胞，这可能是胶质母细胞瘤在常规治疗后复发的关键因素。这强调了有必要探索新的治疗策略，旨在针对侧脑室下区以根除神经干细胞或神经胶质瘤干细胞。在这篇综述中，我们总结了针对侧脑室下区神经干细胞治疗胶质母细胞瘤的最新临床前和临床进展，并阐明了临床应用中的前景和挑战。
尽管仍存在未解决的问题，但目前的进展为我们提供了大量证据，表明针对侧脑室下区的神经干细胞和神经胶质瘤干细胞可能有潜力解决胶质母细胞瘤复发和治疗耐药的困境。
