Shmueli Or, Szeskin Adi, Benhamou Ilan, Joskowicz Leo, Shwartz Yahel, Levy Jaime
Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Ein-Karem, Jerusalem 91120, Israel.
School of Computer Science and Engineering, The Hebrew University of Jerusalem, Givat-Ram, Jerusalem 9190401, Israel.
Bioengineering (Basel). 2024 Aug 19;11(8):849. doi: 10.3390/bioengineering11080849.
The purpose of this study was to compare geographic atrophy (GA) area semi-automatic measurement using fundus autofluorescence (FAF) versus optical coherence tomography (OCT) annotation with the cRORA (complete retinal pigment epithelium and outer retinal atrophy) criteria.
GA findings on FAF and OCT were semi-automatically annotated at a single time point in 36 pairs of FAF and OCT scans obtained from 36 eyes in 24 patients with dry age-related macular degeneration (AMD). The GA area, focality, perimeter, circularity, minimum and maximum Feret diameter, and minimum distance from the center were compared between FAF and OCT annotations.
The total GA area measured on OCT was 4.74 ± 3.80 mm. In contrast, the total GA measured on FAF was 13.47 ± 8.64 mm ( < 0.0001), with a mean difference of 8.72 ± 6.35 mm. Multivariate regression analysis revealed a significant correlation between the difference in area between OCT and FAF and the total baseline lesion perimeter and maximal lesion diameter measured on OCT (adjusted : 0.52; < 0.0001) and the total baseline lesion area measured on FAF (adjusted : 0.83; < 0.0001).
We report that the GA area measured on FAF differs significantly from the GA area measured on OCT. Further research is warranted in order to determine the clinical relevance of these findings.
本研究的目的是比较使用眼底自发荧光（FAF）与光学相干断层扫描（OCT）注释并依据cRORA（完整视网膜色素上皮和外层视网膜萎缩）标准进行的地理萎缩（GA）区域半自动测量。
在24例干性年龄相关性黄斑变性（AMD）患者的36只眼中，对36对FAF和OCT扫描图像在单个时间点进行GA结果的半自动注释。比较FAF和OCT注释之间的GA面积、局灶性、周长、圆形度、最小和最大费雷特直径以及距中心的最小距离。
OCT测量的总GA面积为4.74±3.80平方毫米。相比之下，FAF测量的总GA面积为13.47±8.64平方毫米（<0.0001），平均差异为8.72±6.35平方毫米。多变量回归分析显示，OCT和FAF之间的面积差异与OCT测量的总基线病变周长和最大病变直径（调整后：0.52；<0.0001）以及FAF测量的总基线病变面积（调整后：0.83；<0.0001）之间存在显著相关性。
我们报告FAF测量的GA面积与OCT测量的GA面积存在显著差异。为确定这些发现的临床相关性，有必要进行进一步研究。
