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鉴定为与铜鱼大量死亡相关的病原体（）。 （注：原文括号部分内容缺失，翻译可能不太完整准确）

Identification of as the Pathogen Associated with Massive Mortality in Bronze Gudgeon ().

作者信息

Liu Wenzhi, Li Mengmeng, Xue Mingyang, Zhou Yong, Jiang Nan, Meng Yan, Liu Yisha, Jiang Jingwen, Liao Xiaolin, Fan Yuding

机构信息

Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China.

Graduate School of Chinese Academy of Agricultural Sciences, Beijing 100081, China.

出版信息

Animals (Basel). 2024 Aug 22;14(16):2440. doi: 10.3390/ani14162440.

DOI:10.3390/ani14162440
PMID:39199972
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11350679/
Abstract

, an opportunistic pathogen toward aquatic organisms, was identified as the causative pathogen (isolate WH10) in diseased bronze gudgeon via bacterial isolation, and morphological, physiological, biochemical, and molecular characterization. WH10 exerted its pathogenicity via five virulence genes, including those encoding cytotoxic enterotoxins (act and alt), lipase (lip), a quorum sensing-controlled virulence factor (LuxS), and a Type III secretion system inner membrane component (ascV). WH10 was shown to be sensitive to compound sulfamethoxazoles, cefothiophene, doxycycline, and sulfamethoxazole. Toward bronze gudgeon, WH10 had a median lethal dose (LD) of 1.36 × 10 colony forming units/mL. Analysis of blood parameters of diseased fish revealed significant increases in monocytes and neutrophils, but decreased numbers of lymphocytes. Serum aspartate aminotransferase activity and triglyceride concentration were significantly higher in diseased fish than in healthy fish. The reverse was noted for alkaline phosphatase, total protein, albumin, total cholesterol, and glucose. Thus, is implicated as the causative agent of the mass mortality observed in bronze gudgeon, warranting further investigations into the diagnosis, epidemiology, prevention, and treatment of this infectious disease.

摘要

通过细菌分离以及形态学、生理学、生物化学和分子特征鉴定，一种对水生生物具有机会致病性的病原体被确定为患病青铜 gudgeon 中的致病病原体（分离株 WH10）。WH10 通过五个毒力基因发挥其致病性，包括编码细胞毒性肠毒素（act 和 alt）、脂肪酶（lip）、群体感应控制的毒力因子（LuxS）和 III 型分泌系统内膜成分（ascV）的基因。结果表明 WH10 对复方磺胺甲恶唑、头孢噻吩、强力霉素和磺胺甲恶唑敏感。对于青铜 gudgeon，WH10 的半数致死剂量（LD）为 1.36×10 菌落形成单位/毫升。对患病鱼血液参数的分析显示单核细胞和中性粒细胞显著增加，但淋巴细胞数量减少。患病鱼的血清天冬氨酸转氨酶活性和甘油三酯浓度显著高于健康鱼。碱性磷酸酶、总蛋白、白蛋白、总胆固醇和葡萄糖则相反。因此， 被认为是青铜 gudgeon 中观察到的大规模死亡的病原体，需要对这种传染病的诊断、流行病学、预防和治疗进行进一步调查。 （原文中“ ”部分内容缺失，请补充完整后再准确翻译，这里是按照现有内容进行的翻译）

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1180/11350679/611eb981f21d/animals-14-02440-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1180/11350679/cc754581d1ab/animals-14-02440-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1180/11350679/2bda5a08723e/animals-14-02440-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1180/11350679/9c87c6bcfcae/animals-14-02440-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1180/11350679/838796dd4fd8/animals-14-02440-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1180/11350679/5203b7a9c7e6/animals-14-02440-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1180/11350679/611eb981f21d/animals-14-02440-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1180/11350679/cc754581d1ab/animals-14-02440-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1180/11350679/2bda5a08723e/animals-14-02440-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1180/11350679/9c87c6bcfcae/animals-14-02440-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1180/11350679/838796dd4fd8/animals-14-02440-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1180/11350679/5203b7a9c7e6/animals-14-02440-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1180/11350679/611eb981f21d/animals-14-02440-g006.jpg

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