Ceccopieri Cassandra, Madej Jan P
Department of Immunology, Pathophysiology and Veterinary Preventive Medicine, Wroclaw University of Environmental and Life Sciences, 50-375 Wroclaw, Poland.
Animals (Basel). 2024 Aug 22;14(16):2439. doi: 10.3390/ani14162439.
Recent discoveries have indicated the importance of developing modern strategies for vaccinations, more ethical research models, and effective alternatives to antibiotic treatment in farm animals. Chickens () play a crucial role in this context given the commercial and economic relevance of poultry production worldwide and the search for analogies between the immune systems of humans and birds. Specifically, chicken secondary lymphoid tissues share similar features to their human counterparts. Chickens have several secondary or peripheral lymphoid tissues that are the sites where the adaptive immune response is initiated. The more general classification of these organs divides them into the spleen and skin-, pineal-, or mucosa-associated lymphoid tissues. Each of these tissues is further subdivided into separate lymphoid structures that perform specific and different functions along the animal's body. A review summarizing the state of the art of research on chicken secondary lymphoid organs is of great relevance for the design of future studies.
最近的发现表明，制定现代疫苗接种策略、更符合伦理的研究模型以及农场动物抗生素治疗的有效替代方法具有重要意义。鉴于全球家禽生产的商业和经济相关性，以及对人类和鸟类免疫系统之间相似性的探索，鸡在这方面起着至关重要的作用。具体而言，鸡的二级淋巴组织与其人类对应组织具有相似特征。鸡有几个二级或外周淋巴组织，这些组织是启动适应性免疫反应的部位。这些器官的更一般分类将它们分为脾脏以及与皮肤、松果体或粘膜相关的淋巴组织。这些组织中的每一个都进一步细分为独立的淋巴结构，它们在动物体内执行特定且不同的功能。一篇总结鸡二级淋巴器官研究现状的综述对于未来研究的设计具有重要意义。
