David Audrey, Tahrioui Ali, Tareau Anne-Sophie, Forge Adrien, Gonzalez Mathieu, Bouffartigues Emeline, Lesouhaitier Olivier, Chevalier Sylvie
Univ Rouen Normandie, Univ Caen Normandie, Normandie Univ, CBSA UR 4312, F-76000 Rouen, France.
Antibiotics (Basel). 2024 Jul 24;13(8):688. doi: 10.3390/antibiotics13080688.
is an opportunistic pathogen causing acute and chronic infections, especially in immunocompromised patients. Its remarkable adaptability and resistance to various antimicrobial treatments make it difficult to eradicate. Its persistence is enabled by its ability to form a biofilm. Biofilm is a community of sessile micro-organisms in a self-produced extracellular matrix, which forms a scaffold facilitating cohesion, cell attachment, and micro- and macro-colony formation. This lifestyle provides protection against environmental stresses, the immune system, and antimicrobial treatments, and confers the capacity for colonization and long-term persistence, often characterizing chronic infections. In this review, we retrace the events of the life cycle of biofilm, from surface perception/contact to cell spreading. We focus on the importance of extracellular appendages, mechanical constraints, and the kinetics of matrix component production in each step of the biofilm life cycle.
是一种机会致病菌，可引起急性和慢性感染，尤其是在免疫功能低下的患者中。其显著的适应性和对各种抗菌治疗的耐药性使其难以根除。它能够形成生物膜，从而得以持续存在。生物膜是由固着微生物在自身产生的细胞外基质中形成的群落，该基质形成了一个支架，有助于微生物凝聚、细胞附着以及微菌落和大菌落的形成。这种生存方式可抵御环境压力、免疫系统和抗菌治疗，并赋予其定植和长期持续存在的能力，这通常是慢性感染的特征。在本综述中，我们追溯了生物膜生命周期中的各个事件，从表面感知/接触到细胞扩散。我们重点关注细胞外附属物、机械限制以及生物膜生命周期各阶段中基质成分产生的动力学的重要性。
