Das Smriti, Priyanka Karuppannagounder Rajan, Prabhu Kolandhasamy, Vinayagam Ramachandran, Rajaram Rajendran, Kang Sang Gu
Department of Marine Science, School of Marine Sciences, Bharathidasan University, Tiruchirappalli 620 024, Tamil Nadu, India.
Department of Biotechnology, Institute of Biotechnology, College of Life and Applied Sciences, Yeungnam University, 280 Daehak-Ro, Gyeongsan 38541, Gyeongsangbuk-do, Republic of Korea.
Antibiotics (Basel). 2024 Aug 9;13(8):748. doi: 10.3390/antibiotics13080748.
Tidal wetlands, commonly known as salt marshes, are highly productive ecosystems in temperate regions worldwide. These environments constitute a unique flora composed primarily of salt-tolerant herbs, grasses, and shrubs. This study investigated the therapeutic properties of ten salt marsh plants collected mainly from Palk Bay and Mannar Gulf against Candida disease. This study examined the changes in natural plant products associated with their anti-Candida growth activity during two distinct seasonal changes-monsoon and summer. The potential of the salt marshes to inhibit the growth of five different strains was assessed using four solvents. In phytochemical analysis, the extracts obtained from a exhibited the highest results compared to the other plant extracts. Fourier transform infrared spectroscopy revealed 12 peaks with alkane, aldehyde, amine, aromatic ester, phenol, secondary alcohol, and 1,2,3,4-tetrasubstituted. Gas-chromatography-mass spectrometry detected 30 compounds. Cyclotetracosane, lupeol, β-amyrin, and 12-oleanen-3-yl acetate showed the highest peak range. In particular, plant samples collected during the monsoon season were more effective in preventing Canda growth than the summer plant samples. In the monsoon season, the salt marsh plant extracted with ethyl acetate showed a high anti-Candida growth activity, while in the summer, the acetone extract exhibited a higher anti-Candida growth activity than the other solvents. The hexane extract of showed the highest inhibition zone against all Candidal strains. Furthermore, compounds, such as β-amyrin, lupeol, and oxirane, from the hexane extract of play a vital role in anti-Candida activity. This paper reports the potential of tidal marsh plant extracts for developing new antifungal agents for Candida infections.
潮汐湿地，通常被称为盐沼，是全球温带地区高生产力的生态系统。这些环境构成了一个独特的植物群落，主要由耐盐草本植物、禾本科植物和灌木组成。本研究调查了主要从保克湾和马纳尔湾采集的十种盐沼植物对念珠菌病的治疗特性。本研究考察了在季风和夏季这两个不同季节变化期间，天然植物产物与其抗念珠菌生长活性相关的变化。使用四种溶剂评估了盐沼抑制五种不同菌株生长的潜力。在植物化学分析中，与其他植物提取物相比，从a中获得的提取物显示出最高的结果。傅里叶变换红外光谱显示有12个峰，分别为烷烃、醛、胺、芳香酯、酚、仲醇和1,2,3,4 - 四取代物。气相色谱 - 质谱法检测到30种化合物。环二十四烷、羽扇豆醇、β - 香树脂醇和乙酸12 - 齐墩果烯 - 3 - 醇酯显示出最高的峰面积范围。特别是，在季风季节采集的植物样本在预防念珠菌生长方面比夏季植物样本更有效。在季风季节，用乙酸乙酯提取的盐沼植物表现出高抗念珠菌生长活性，而在夏季，丙酮提取物表现出比其他溶剂更高的抗念珠菌生长活性。a的己烷提取物对所有念珠菌菌株显示出最高的抑菌圈。此外，来自a的己烷提取物中的β - 香树脂醇、羽扇豆醇和环氧乙烷等化合物在抗念珠菌活性中起重要作用。本文报道了潮汐沼泽植物提取物在开发用于念珠菌感染的新型抗真菌剂方面的潜力。
