Galos Felicia, Ionescu Mara Ioana, Mirea Mihai Daniel Luca, Boboc Anca Andreea, Ioan Andreea, Boboc Catalin
Department of Pediatrics, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Department of Pediatrics, Marie Curie Emergency Children's Hospital, 041451 Bucharest, Romania.
Antibiotics (Basel). 2024 Aug 10;13(8):752. doi: 10.3390/antibiotics13080752.
Upper gastrointestinal bleeding (UGIB) is a significant concern in children, contributing to 6-20% of cases in pediatric intensive care units. This study evaluates the roles of () infection and non-steroidal anti-inflammatory drug (NSAID) usage in the etiology of UGIB in children, with a particular focus on trends observed during the COVID-19 pandemic. We conducted a retrospective analysis of 103 pediatric patients who underwent esophagogastroduodenoscopy (EGD) for UGIB between January 2015 and December 2023. Of these, 88 patients were included in the final analysis, where the source of bleeding was successfully identified. Hematemesis was the most common presentation, and the source of bleeding was identified in 85.43% of cases. The prevalence of infection remained stable across the pre-pandemic (39.7%) and post-pandemic (36.7%) periods. However, NSAID usage increased nearly threefold during the pandemic, with 36.7% of post-pandemic UGIB cases associated with NSAID use, compared to 12.1% pre-pandemic. These findings underscore the significant roles of and NSAID use in pediatric UGIB, with a notable increase in NSAID-related cases during the pandemic.
上消化道出血（UGIB）是儿童中的一个重要问题，在儿科重症监护病房的病例中占6%-20%。本研究评估了（）感染和非甾体抗炎药（NSAID）的使用在儿童UGIB病因中的作用，特别关注在新冠疫情期间观察到的趋势。我们对2015年1月至2023年12月期间因UGIB接受食管胃十二指肠镜检查（EGD）的103例儿科患者进行了回顾性分析。其中，88例患者被纳入最终分析，出血源被成功识别。呕血是最常见的表现，85.43%的病例中出血源被识别。（）感染的患病率在疫情前（39.7%）和疫情后（36.7%）期间保持稳定。然而，在疫情期间NSAID的使用增加了近三倍，疫情后UGIB病例中有36.7%与NSAID使用有关，而疫情前为12.1%。这些发现强调了（）和NSAID使用在儿科UGIB中的重要作用，在疫情期间与NSAID相关的病例显著增加。
