Nguyen Tu Cam, Tang Ngoc Le Chau, Le Giao Kim Ngoc, Nguyen Vy Thuy, Nguyen Khuong Hoang Gia, Che Thai Hoang, Phan Van Thi Tuong, Nguyen Ngoc Minh, Truong Dinh Quang, Ngo Xuan Minh, Nguyen Hiep Thanh, Robert Annie, Bontems Patrick, Nguyen Phuong Ngoc Van
Department of Gastroenterology, City Children's Hospital, Ho Chi Minh City 700000, Vietnam.
Faculty of Medicine, Université Libre de Bruxelles, 1020 Brussels, Belgium.
Healthcare (Basel). 2023 Jun 5;11(11):1658. doi: 10.3390/healthcare11111658.
() remains a major cause of gastroduodenal diseases. We aimed to evaluate the burden of this infection, particularly peptic ulcer disease in Vietnamese children.
We enrolled consecutive children referred for esophagogastroduodenoscopy at two tertiary children's hospitals in Ho Chi Minh City, from October 2019 to May 2021. Children treated with proton pump inhibitors during the last two weeks or antibiotics for four weeks, and those having a previous or interventional endoscopy were excluded. infection was diagnosed with either a positive culture or positive histopathology combined with a rapid urease test, or with a polymerase chain reaction of the urease gene. The study was approved by the Ethics Committee and written informed consent/assent was obtained.
Among 336 enrolled children aged 4-16 (mean: 9.1 ± 2.4 years; 55.4% girls), infection was positive in 80%. Peptic ulcers were detected in 65 (19%), increasing with age, and 25% with anemia. strains were detected at a higher rate in children with ulcers.
Prevalence of and peptic ulcers is high among symptomatic Vietnamese children. It is crucial to have a program for early detection of to reduce ulcer risk and gastric cancer later.
（）仍然是胃十二指肠疾病的主要病因。我们旨在评估这种感染的负担，尤其是越南儿童的消化性溃疡疾病。
我们纳入了2019年10月至2021年5月期间在胡志明市两家三级儿童医院接受食管胃十二指肠镜检查的连续儿童。排除在过去两周内接受质子泵抑制剂治疗或四周内接受抗生素治疗的儿童，以及曾接受过内镜检查或介入性内镜检查的儿童。通过阳性培养或阳性组织病理学检查结合快速尿素酶试验，或通过尿素酶基因的聚合酶链反应诊断感染。该研究获得了伦理委员会的批准，并获得了书面知情同意/同意书。
在336名年龄在4至16岁（平均：9.1±2.4岁；55.4%为女孩）的纳入儿童中，80%的感染呈阳性。65名（19%）儿童检测出消化性溃疡，其发生率随年龄增长而增加，25%的患儿伴有贫血。溃疡患儿中检测到（）菌株的比例更高。
有症状的越南儿童中（）和消化性溃疡的患病率很高。制定早期检测（）的计划以降低后期溃疡风险和胃癌风险至关重要。
