Smyła-Gruca Wiktoria, Szczurek-Wasilewicz Wioletta, Skrzypek Michał, Romuk Ewa, Karmański Andrzej, Jurkiewicz Michał, Gąsior Mariusz, Osadnik Tadeusz, Banach Maciej, Jóźwiak Jacek J, Szyguła-Jurkiewicz Bożena
Student's Scientific Society, 3rd Department of Cardiology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.
2nd Department of Cardiology and Angiology, Silesian Center for Heart Diseases, 41-800 Zabrze, Poland.
Biomedicines. 2024 Aug 6;12(8):1767. doi: 10.3390/biomedicines12081767.
Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and cells' ability to neutralize them by antioxidant systems. The role of oxidative stress in hypertrophic cardiomyopathy (HCM) is not fully understood. The aim of the study was to examine selected parameters of oxidative stress in patients with HCM compared to the control group. We enrolled 85 consecutive HCM patients and 97 controls without HCM. The groups were matched for sex, the body mass index, and age. Oxidative stress markers included superoxide dismutase (SOD), ceruloplasmin (CER), and lipofuscin (LPS). The median age of the HCM patients was 53 (40-63) years, and 41.2% of them were male. HCM patients, compared to the control ones, had significantly increased levels of CER and LPS. The areas under the receiver operating characteristics curves (AUC) indicated a good discriminatory power of CER (AUC 0.924, sensitivity 84%, and specificity 88%), an acceptable discriminatory power of LPS (AUC 0.740, sensitivity 66%, and specificity 72%), and poor discriminatory power of SOD (AUC 0.556, sensitivity 34%, and specificity 94%) for HCM detection. CER with good predictive strength, as well as LPS with acceptable predictive power, allows for HCM detection. The utility of SOD for HCM detection is limited.
氧化应激反映了活性氧的全身表现与细胞通过抗氧化系统中和它们的能力之间的失衡。氧化应激在肥厚型心肌病（HCM）中的作用尚未完全明确。本研究的目的是比较肥厚型心肌病患者与对照组氧化应激的选定参数。我们连续纳入了85例肥厚型心肌病患者和97例非肥厚型心肌病对照组。两组在性别、体重指数和年龄方面相匹配。氧化应激标志物包括超氧化物歧化酶（SOD）、铜蓝蛋白（CER）和脂褐素（LPS）。肥厚型心肌病患者的中位年龄为53（40 - 63）岁，其中41.2%为男性。与对照组相比，肥厚型心肌病患者的CER和LPS水平显著升高。受试者工作特征曲线（AUC）下面积表明，CER对肥厚型心肌病检测具有良好的鉴别能力（AUC 0.924，敏感性84%，特异性88%），LPS具有可接受的鉴别能力（AUC 0.740，敏感性66%，特异性72%），而SOD的鉴别能力较差（AUC 0.556，敏感性34%，特异性94%）。具有良好预测强度的CER以及具有可接受预测能力的LPS可用于肥厚型心肌病检测。SOD用于肥厚型心肌病检测的效用有限。
