揭示一种皮肤科罕见病：外阴上皮内瘤变III级（高级别鳞状上皮内病变）之谜及p53在其发展中的作用。
Unveiling a Dermatological Rarity: The Enigma of Vulvar Intraepithelial Neoplasia Grade III (HSIL) and the Role of p53 in Its Development.
作者信息
Brzeziński Piotr, Feszak Igor, Ortiz Beatriz Di Martino, Feszak Sylwia, Kawczak Piotr, Bączek Tomasz
机构信息
Institute of Health Sciences, Pomeranian University in Słupsk, 76-200 Słupsk, Poland.
Dermatology Department, Clinicas Hospital, Faculty of Medical Sciences, National University of Ausunción, San Lorenzo 111421, Paraguay.
出版信息
Biomedicines. 2024 Aug 8;12(8):1799. doi: 10.3390/biomedicines12081799.
Vulvar intraepithelial neoplasia, also known as VIN, is a non-invasive squamous lesion and precursor of squamous cell carcinoma (SCC) of the vulva. There is no screening test for vulvar intraepithelial neoplasia. Diagnosis of VIN is made clinically and confirmed with a biopsy. We describe a 66-year-old woman with a condyloma-like tumour located in the skin on the vestibule of the vagina. A biopsy sample was taken from the nodule. The definitive diagnosis is supported by the histological examination (VIN III) and immunohistochemical examination of p16(+), p53(+), and a few cell nuclei. The case provides information on the importance of multidisciplinary cooperation. Lifelong surveillance is essential since the resection of individual lesions does not guarantee the prevention of invasive cancer.
外阴上皮内瘤变，也称为VIN，是一种非侵袭性鳞状病变，是外阴鳞状细胞癌（SCC）的前驱病变。目前尚无针对外阴上皮内瘤变的筛查试验。VIN的诊断通过临床做出，并经活检证实。我们描述了一名66岁女性，其阴道前庭皮肤上有一个尖锐湿疣样肿瘤。从结节处取了活检样本。组织学检查（VIN III级）以及p16（阳性）、p53（阳性）和少数细胞核的免疫组化检查支持了明确诊断。该病例提供了关于多学科合作重要性的信息。由于切除单个病变并不能保证预防浸润性癌，因此终身监测至关重要。
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