Yang Teng-Kai, Wang Yu-Jen, Li Hsing-Ju, Yu Ya-Fang, Huang Kai-Wen, Cheng Jason Chia-Hsien
Department of Surgery, Yonghe Cardinal Tien Hospital, New Taipei City 23445, Taiwan.
School of Medicine, College of Medicine, Fu-Jen Catholic University, New Taipei City 242062, Taiwan.
J Clin Med. 2024 Aug 12;13(16):4724. doi: 10.3390/jcm13164724.
Radiation-induced hemorrhagic cystitis (RHC) is a chronic inflammatory disease in patients undergoing radiation therapy that causes a cluster of symptoms which may have a latent period of months to years. The current non-invasive treatments include drug treatment and hyperbaric oxygen therapy (HBOT), which has been widely applied for RHC so far but with limited evidence. Thus, we conducted a systematic review and meta-analysis to clarify the effects and safety of HBOT for RHC. A systematic review and meta-analysis were utilized, searching in the databases of Embase, Pubmed, and Web of Science. The primary endpoint of the present study was complete remission of hematuria. The meta-analysis was conducted using a random effects model, and a pooled odds ratio with 95% CI was calculated. A total of 317 studies were searched and fourteen articles with 556 patients were collected. The results showed that a total of 500 patients (89.9%) had symptom improvement, and the pooled results demonstrated that 55% of patients with HBOT had complete remission of hematuria (95% CI 51-59%). A significant improvement of symptoms when treated with HBOT was shown in this meta-analysis for patients with RHC.
放射性出血性膀胱炎（RHC）是接受放射治疗患者中的一种慢性炎症性疾病，会引发一系列症状，这些症状可能有数月至数年的潜伏期。目前的非侵入性治疗方法包括药物治疗和高压氧治疗（HBOT），到目前为止，HBOT已广泛应用于RHC，但证据有限。因此，我们进行了一项系统评价和荟萃分析，以阐明HBOT治疗RHC的疗效和安全性。我们利用系统评价和荟萃分析，在Embase、Pubmed和Web of Science数据库中进行检索。本研究的主要终点是血尿完全缓解。荟萃分析采用随机效应模型进行，并计算了合并比值比及95%置信区间。共检索到317项研究，收集了14篇文章，涉及556例患者。结果显示，共有500例患者（89.9%）症状改善，汇总结果表明，接受HBOT治疗的患者中有55%血尿完全缓解（95%置信区间51-59%）。这项荟萃分析表明，HBOT治疗RHC患者时症状有显著改善。
