Department of Radiation Biological Effects, French Armed Forces Biomedical Research Institute, 91220 Brétigny-sur-Orge, France.
Clinical Unit Research, HIA Bégin, 94160 Saint-Mandé, France.
Cells. 2020 Dec 24;10(1):21. doi: 10.3390/cells10010021.
Radiation cystitis is a potential complication following the therapeutic irradiation of pelvic cancers. Its clinical management remains unclear, and few preclinical data are available on its underlying pathophysiology. The therapeutic strategy is difficult to establish because few prospective and randomized trials are available. In this review, we report on the clinical presentation and pathophysiology of radiation cystitis. Then we discuss potential therapeutic approaches, with a focus on the immunopathological processes underlying the onset of radiation cystitis, including the fibrotic process. Potential therapeutic avenues for therapeutic modulation will be highlighted, with a focus on the interaction between mesenchymal stromal cells and macrophages for the prevention and treatment of radiation cystitis.
放射性膀胱炎是盆腔癌症治疗性放疗后的潜在并发症。其临床管理仍不清楚，其潜在病理生理学的临床前数据也很少。由于缺乏前瞻性和随机试验，治疗策略难以确立。在这篇综述中，我们报告了放射性膀胱炎的临床表现和病理生理学。然后我们讨论了潜在的治疗方法，重点是放射性膀胱炎发病的免疫病理过程，包括纤维化过程。我们将重点介绍治疗调节的潜在治疗途径，特别是间充质基质细胞和巨噬细胞之间的相互作用，以预防和治疗放射性膀胱炎。
