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铁剂治疗的疗效:对贫血孕妇使用四种铁制剂的比较评估

Efficacy of iron therapy: a comparative evaluation of four iron preparations administered to anaemic pregnant women.

作者信息

Fochi F, Ciampini M, Ceccarelli G

出版信息

J Int Med Res. 1985;13(1):1-11. doi: 10.1177/030006058501300101.

Abstract

The authors conducted a clinical investigation on sixty-nine pregnant women, anaemic and non-anaemic, the purpose being to assess the effect of 50 days treatment with four different medicinal iron preparations, namely, ferrous sulphate, iron chondroitinsulfuric acid complex, and ferritin alone or associated with folinic acid and cobamamide, on various haematological parameters (Hb, RCC, Ht, CV, Iron, and Transferrin IBC). The four products demonstrated a similar efficacy in maintaining anaemic conditions under control; moreover, the results confirmed our hypothesis of the absorption of iron ferritin. While three products were well tolerated, ferrous sulphate induced, in some cases, side-effects.

摘要

作者对69名孕妇进行了临床研究,这些孕妇有贫血和非贫血的情况,目的是评估用四种不同的药用铁制剂(即硫酸亚铁、铁-硫酸软骨素复合物、单独的铁蛋白或与亚叶酸和钴胺酰胺联合使用)进行50天治疗对各种血液学参数(血红蛋白、红细胞计数、血细胞比容、红细胞体积分布宽度、铁和转铁蛋白铁结合能力)的影响。这四种产品在控制贫血状况方面显示出相似的疗效;此外,结果证实了我们关于铁蛋白中铁吸收的假设。虽然三种产品耐受性良好,但硫酸亚铁在某些情况下会引起副作用。

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