Shaanxi Key Laboratory of Chinese Jujube, College of Life Sciences, Yan'an University, Yan'an 716000, China.
Int J Mol Sci. 2024 Aug 7;25(16):8611. doi: 10.3390/ijms25168611.
is an opportunistic pathogen that requires iron to survive in the host; however, the host immune system limits the availability of iron. Pyochelin (PCH) is a major siderophore produced by during infection, which can help survive in an iron-restricted environment and cause infection. The infection activity of is regulated by the quinolone signal (PQS) quorum-sensing system. The system uses 2-heptyl-3-hydroxy-4-quinolone (PQS) or its precursor, 2-heptyl-4-quinolone (HHQ), as the signal molecule. PQS can control specific life processes such as mediating quorum sensing, cytotoxicity, and iron acquisition. This review summarizes the biosynthesis of PCH and PQS, the shared transport system of PCH and PQS, and the regulatory relationship between PCH and PQS. The correlation between the PQS and PCH is emphasized to provide a new direction for future research.
是一种机会性病原体，需要铁才能在宿主体内存活;然而，宿主的免疫系统限制了铁的可用性。绿脓菌素（PCH）是 感染时产生的主要铁载体，它可以帮助 在缺铁环境中存活并引起感染。 的感染活性受 喹诺酮信号（PQS）群体感应系统调节。该系统使用 2-庚基-3-羟基-4-喹诺酮（PQS）或其前体 2-庚基-4-喹诺酮（HHQ）作为信号分子。PQS 可以控制特定的生命过程，如介导群体感应、细胞毒性和铁摄取。本综述总结了 PCH 和 PQS 的生物合成、PCH 和 PQS 的共享运输系统以及 PCH 和 PQS 之间的调控关系。强调了 PQS 和 PCH 之间的相关性，为未来的研究提供了新的方向。
