Peruzzo Arianna, Vascellari Marta, Massaro Andrea, Mancin Marzia, Stefani Annalisa, Orsini Massimiliano, Danesi Patrizia, Petrin Sara, Carminato Antonio, Santoro Michele Matteo, Speranza Roberto, Losasso Carmen, Capelli Gioia
Laboratory of Microbial Ecology and Genomics, Istituto Zooprofilattico Sperimentale delle Venezie, 35020 Legnaro, Italy.
Laboratory of Histopathology, Istituto Zooprofilattico Sperimentale delle Venezie, 35020 Legnaro, Italy.
Animals (Basel). 2023 Mar 7;13(6):958. doi: 10.3390/ani13060958.
() is a worldwide cause of acute diarrheal disease both in humans and animals. The primary aim of this study was to investigate possible variations in gut microbiota in a population of asymptomatic dogs ( = 31), naturally infected or not by . Gut microbiota and the hematological, biochemical, and fecal parameters related to intestinal function were investigated. infection was associated with a significant shift of beta diversity, showing a relevant reduction of Gammaproteobacteria and an increase of Fusobacteria in male-positive dogs if compared with negatives. A significant imbalance of different bacterial taxa, with particular reference to the , , , and orders, was observed, with the first two being higher in -positive dogs. -positive males displayed significantly higher values of cCRP than negative males as well as positive females, supporting the presence of a pro-inflammatory state. Taken together, these results indicate that the presence of does not substantially modify the microbial ecology of the intestine nor the hematological markers of disease. Thus treatments against should be considered with caution in asymptomatic subjects.
（）是一种在人类和动物中引起急性腹泻病的全球性病因。本研究的主要目的是调查一群无症状犬（n = 31）的肠道微生物群可能存在的差异，这些犬是否自然感染了（）。研究了肠道微生物群以及与肠道功能相关的血液学、生化和粪便参数。与阴性犬相比，（）感染与β多样性的显著变化相关，在雄性阳性犬中γ-变形菌显著减少，梭杆菌增加。观察到不同细菌类群存在显著失衡，特别是（）、（）、（）和（）菌目，前两者在（）阳性犬中更高。（）阳性雄性犬的cCRP值显著高于阴性雄性犬以及阳性雌性犬，这支持了炎症前状态的存在。综上所述，这些结果表明（）的存在并未实质性改变肠道微生物生态或疾病的血液学标志物。因此，对于无症状个体，应谨慎考虑针对（）的治疗方法。
