Rópolo Andrea S, Touz Maria C
Instituto de Investigación Médica Mercedes y Martín Ferreyra, INIMEC – CONICET, Córdoba. Argentina.
ScientificWorldJournal. 2010 Oct 12;10:2019-31. doi: 10.1100/tsw.2010.200.
In the relationships between host and parasites, there is a cross-talk that involves diverse mechanisms developed by two different genetic systems during years of evolution. On the one hand, immunocompetent hosts have developed effective innate and acquired immune responses that are used to restrict or avoid parasitism. On the other hand, parasites evade the immune response, expressing different antigens on their surface or by using other specific mechanisms, such as nutrient depletion. In this review, we analyze the survival mechanisms used by the protozoan parasite Giardia lamblia during infection. In particular, we examine the multiple roles played by the enzyme arginine deiminase during colonization of the gut, also involving the parasite's mechanism of antigenic variation. Potential drug targets for the treatment of giardiasis are also discussed.
在宿主与寄生虫的关系中，存在一种相互作用，涉及两个不同遗传系统在多年进化过程中形成的多种机制。一方面，具有免疫能力的宿主已发展出有效的先天性和后天性免疫反应，用于限制或避免寄生虫感染。另一方面，寄生虫通过在其表面表达不同抗原或利用其他特定机制（如营养耗竭）来逃避免疫反应。在本综述中，我们分析了原生动物寄生虫蓝氏贾第鞭毛虫在感染过程中所采用的生存机制。特别地，我们研究了精氨酸脱亚氨酶在肠道定植过程中所起的多重作用，这也涉及寄生虫的抗原变异机制。此外，还讨论了治疗贾第虫病的潜在药物靶点。
