Ren Dong, Lou Jerry, Kuan Edward, Perez-Rosendahl Mari, Yong William H
Department of Pathology and Laboratory Medicine, University of California, Irvine, CA 92697, USA.
Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, CA 92697, USA.
Diagnostics (Basel). 2024 Aug 9;14(16):1731. doi: 10.3390/diagnostics14161731.
Meningiomas are tumors originating from arachnoid meningothelial cells. Occasionally, meningiomas are identified outside the central nervous system, and are referred to as extracranial meningiomas (EMs). The vast majority of EMs are an extension from an intracranial or intraspinal tumor. However, primary EMs may arise from extracranial sites with the most common sites being the skin and scalp subcutis, which are further categorized as cutaneous meningiomas (CMs). CMs are rare cutaneous tumors with similar ultrastructural and cytologic findings compared to those of intracranial meningiomas, but with a wide range of histologic differences. Therefore, an assessment using a panel of investigative tools, including imaging, histopathology, and immunohistochemistry, is required to determine the diagnosis of CMs. Here, we report the case of a 64-year-old gentleman presenting with a posttraumatic well-circumscribed superficial mass overlying the right nasal bridge. We are unable to identify other cases arising in the nasal bridge.
脑膜瘤是起源于蛛网膜脑膜内皮细胞的肿瘤。偶尔,脑膜瘤在中枢神经系统外被发现,被称为颅外脑膜瘤(EMs)。绝大多数EMs是颅内或椎管内肿瘤的延伸。然而,原发性EMs可能起源于颅外部位,最常见的部位是皮肤和头皮皮下组织,这进一步被归类为皮肤脑膜瘤(CMs)。CMs是罕见的皮肤肿瘤,与颅内脑膜瘤相比,具有相似的超微结构和细胞学特征,但在组织学上有广泛差异。因此,需要使用包括影像学、组织病理学和免疫组织化学在内的一系列检查工具进行评估,以确定CMs的诊断。在此,我们报告一例64岁男性患者,其右鼻梁上方有一个创伤后边界清晰的浅表肿块。我们未能找到其他发生在鼻梁的病例。