Tunç Abdulkadir, Danisan Gurkan, Taydas Onur, Kara Ahmet Burak, Öncel Samet, Özdemir Mustafa
Department of Neurology, Faculty of Medicine, Sakarya University, 54100 Sakarya, Turkey.
Department of Radiology, Faculty of Medicine, Sakarya University, 54100 Sakarya, Turkey.
Diagnostics (Basel). 2024 Aug 13;14(16):1760. doi: 10.3390/diagnostics14161760.
Alterations in the cerebral venous system have been increasingly recognized as a significant component of the pathophysiology of multiple sclerosis (MS). This study aimed to explore the relationship between venous sinus diameter and MS to understand potential vascular alterations in MS patients compared with controls. We sought to determine whether these alterations were correlated with disease characteristics such as duration, lesion type, and disability score.
This study included 79 MS patients diagnosed according to the 2017 McDonald criteria and 67 healthy individuals. Magnetic resonance imaging (MRI) scans via a 1.5 Tesla system provided measurements of the superior sagittal sinus, right and left transverse sinus, sinus rectus, and venous structures. Statistical analysis was conducted via SPSS, employing independent sample t tests, ANOVA, chi-square tests, and Pearson correlation analysis, with the significance level set at < 0.05.
This study revealed significant differences in venous sinus diameter between MS patients and controls, with MS patients exhibiting larger diameters. Specifically, patients with brainstem and spinal lesions had larger diameters in certain sinus regions. No significant correlations were found between venous sinus diameter and demographic factors, expanded disability status scale scores, or lesion counts. However, a significant increase in perivenular lesions was noted in patients with longer disease durations.
The findings indicate notable vascular alterations in MS patients, particularly in venous sinus diameters, suggesting a potential vascular component in MS pathology. The lack of correlation with conventional clinical and MRI metrics highlights the complexity of MS pathology. These insights underscore the need for further research, particularly longitudinal studies, to elucidate the role of venous changes in MS progression and their potential as therapeutic targets.
脑静脉系统的改变日益被认为是多发性硬化症（MS）病理生理学的重要组成部分。本研究旨在探讨静脉窦直径与MS之间的关系，以了解MS患者与对照组相比潜在的血管改变。我们试图确定这些改变是否与疾病特征如病程、病变类型和残疾评分相关。
本研究纳入了79例根据2017年麦克唐纳标准诊断的MS患者和67名健康个体。通过1.5特斯拉系统进行的磁共振成像（MRI）扫描提供了上矢状窦、左右横窦、直窦和静脉结构的测量数据。通过SPSS进行统计分析，采用独立样本t检验、方差分析、卡方检验和Pearson相关分析，显著性水平设定为<0.05。
本研究揭示了MS患者与对照组之间静脉窦直径存在显著差异，MS患者的直径更大。具体而言，脑干和脊髓有病变的患者在某些窦区直径更大。未发现静脉窦直径与人口统计学因素、扩展残疾状态量表评分或病变数量之间存在显著相关性。然而，病程较长的患者静脉周围病变显著增加。
研究结果表明MS患者存在明显的血管改变，尤其是静脉窦直径，提示MS病理中存在潜在的血管成分。与传统临床和MRI指标缺乏相关性凸显了MS病理的复杂性。这些见解强调了进一步研究的必要性，特别是纵向研究，以阐明静脉变化在MS进展中的作用及其作为治疗靶点的潜力。
