Department of Medical Imaging, John Hunter Hospital, Newcastle, NSW, Australia; Newcastle University Faculty of Health, Callaghan Campus, Newcastle, NSW, Australia.
School of Mechanical Engineering, University of New South Wales, Sydney, NSW, Australia.
Mult Scler Relat Disord. 2023 Aug;76:104843. doi: 10.1016/j.msard.2023.104843. Epub 2023 Jun 20.
There is a significant increase in the parenchymal microvessel blood volume in the earliest forms of multiple sclerosis (MS) which may be due to venular dilatation. Increased cortical venous pressure could account for this finding. Venous pressure is also implicated in the physiology of fatigue. The purpose of this study is to discover if there is dilatation of the veins within the subarachnoid space in multiple sclerosis and to estimate the pressures required to maintain any enlargement found. These findings will be correlated with the fatigue symptoms found in MS.
103 patients with MS were compared with a control group of 50 patients. Post contrast 3DT1 images were used. The cross-sectional area of the bridging cortical veins and the vein of Galen were measured.
In MS, the superficial territory cortical veins were 29% larger and the veins of Galen were 25% larger than the controls.
There is evidence of a significant increase in the bridging vein transmural pressure in MS, estimated to be approximately 6.5 mmHg in the superficial cortical veins. MS patients with significant fatigue have larger cortical veins than those who are not significantly fatigued.
多发性硬化症（MS）的最早阶段，实质微血管内的血容量显著增加，这可能是由于小静脉扩张所致。皮质静脉压升高可能是造成这种现象的原因。静脉压也与疲劳的生理机制有关。本研究的目的是发现多发性硬化症患者蛛网膜下腔的静脉是否有扩张，并估计维持任何发现的扩张所需的压力。这些发现将与多发性硬化症中发现的疲劳症状相关联。
将 103 例多发性硬化症患者与 50 例对照组患者进行比较。使用对比增强 3DT1 图像。测量桥接皮质静脉和Galen 静脉的横截面积。
在多发性硬化症中，浅表性皮质静脉的横截面积比对照组大 29%，Galen 静脉的横截面积比对照组大 25%。
多发性硬化症患者桥接静脉壁间压有明显升高的证据，估计在浅表性皮质静脉中约为 6.5mmHg。有明显疲劳症状的多发性硬化症患者的皮质静脉比没有明显疲劳症状的患者大。
