Alqaidy Doaa, Althomali Hind, Almaghrabi Amal
Department of Pathology, King Abdulaziz University, Jeddah 22252, Saudi Arabia.
Hematology Research Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 22252, Saudi Arabia.
Diagnostics (Basel). 2024 Aug 17;14(16):1801. doi: 10.3390/diagnostics14161801.
Lymphadenopathy is a common presentation of both reactive and malignant diseases, and lymph node fine-needle aspiration cytology (LN-FNAC) is an effective and inexpensive screening method. It can prevent unnecessary invasive surgery and excisional biopsy, especially in benign cases. Unfortunately, the lack of universally accepted terminology for reporting results has hindered its widespread support. The Sydney system proposal for lymph node cytopathology categorization and reporting introduced five diagnostic categories to address the lack of universally accepted terminology for reporting results in lymphadenopathy. Our study analyzed 188 lymph node fine-needle cytology (FNC) samples from King Abdulaziz University Hospital, Saudi Arabia, examining clinical follow-up data, pathology records, patient information, and final diagnosis from January 2019 to December 2022. Most specimens were from axillary lymph nodes, with 99.5% tissue correlation. The Sydney system category classification identified 56.9% of cases as malignant, while 26.1% were benign. The final surgical specimen diagnosis revealed a higher percentage of malignant diagnoses, with the highest risk of malignancy (ROM) in malignant/category V. In conclusion, our study demonstrates that LN-FNAC offers high diagnostic accuracy for lymph node (LN) aspirates, with the Sydney approach potentially aiding risk stratification and achieving consistency in cytologic diagnosis, but further multi-centric research is needed.
淋巴结病是反应性疾病和恶性疾病的常见表现，淋巴结细针穿刺细胞学检查（LN-FNAC）是一种有效且廉价的筛查方法。它可以避免不必要的侵入性手术和切除活检，尤其是在良性病例中。不幸的是，缺乏普遍接受的报告结果术语阻碍了其广泛应用。悉尼系统关于淋巴结细胞病理学分类和报告的提议引入了五个诊断类别，以解决淋巴结病报告结果缺乏普遍接受术语的问题。我们的研究分析了沙特阿拉伯阿卜杜勒阿齐兹国王大学医院的188份淋巴结细针细胞学（FNC）样本，审查了2019年1月至2022年12月的临床随访数据、病理记录、患者信息和最终诊断。大多数标本来自腋窝淋巴结，组织相关性为99.5%。悉尼系统类别分类将56.9%的病例鉴定为恶性，而26.1%为良性。最终手术标本诊断显示恶性诊断的百分比更高，恶性/类别V的恶性风险（ROM）最高。总之，我们的研究表明，LN-FNAC对淋巴结（LN）抽吸物具有较高的诊断准确性，悉尼方法可能有助于风险分层并实现细胞学诊断的一致性，但需要进一步的多中心研究。
