Department of Ophthalmology, University General Hospital of Ioannina, 45500 Ioannina, Greece.
Department of Hygiene and Epidemiology, Medical School, University of Ioannina, 45500 Ioannina, Greece.
Medicina (Kaunas). 2024 Aug 1;60(8):1254. doi: 10.3390/medicina60081254.
: Recent studies have focused on the association between the risk of diabetic retinopathy (DR) and the rs1501299 and rs2241766 polymorphisms of the ADIPOQ gene; however, their results remain inconclusive. Thus, a systematic review and meta-analysis were carried out to clarify the role of these polymorphisms in the development of DR. : A systematic search of electronic databases (PubMed, Scopus, and Cochrane Library) was conducted until 25 June 2024, and a reference list of relevant articles was collected, which explored the association between the rs1501299 and rs2241766 polymorphisms of the ADIPOQ gene and the risk of DR. The pooled odds ratios (OR) and 95% confidence intervals (CI) were estimated via random-effects model, and the meta-analysis was implemented by using Review Manager 5.4. : In total, 6 out of 182 studies, with 1888 cases (DR) and 2285 controls (without DR), were included in the meta-analysis. A statistically significant association between the rs1501299 polymorphism and the DR risk was recorded in G vs. T in the overall analysis (OR = 0.84, 95% CI = 0.72-0.99, = <0.05, I = 23%, = 5 studies). Additionally, the summary results in the subgroup analysis according to the control type were as follows: the DR versus diabetes mellitus (DM) control type revealed a statistically significant association in G vs. T: OR = 0.81, 95% CI = 0.67-0.97, = <0.05, I = 27%, = 4 studies; GG vs. GT: OR = 0.72, 95% CI = 0.53-0.98, = <0.05, I = 49%, n = 4 studies; GG vs. (GT + TT): OR = 0.73, 95% CI = 0.55-0.96, = <0.05, I = 44%, = 4 studies. No significant association was observed between the rs2241766 polymorphism and the DR risk. : The current meta-analysis supports the association between the rs1501299 polymorphism of the ADIPOQ gene and the DR risk in patients with DM.
最近的研究集中在糖尿病视网膜病变（DR）风险与 ADIPOQ 基因的 rs1501299 和 rs2241766 多态性之间的关联上；然而，他们的结果仍不确定。因此，进行了系统评价和荟萃分析，以阐明这些多态性在 DR 发展中的作用。
系统地搜索了电子数据库（PubMed、Scopus 和 Cochrane Library），直到 2024 年 6 月 25 日，并收集了相关文章的参考文献列表，探讨了 ADIPOQ 基因的 rs1501299 和 rs2241766 多态性与 DR 风险之间的关系。通过随机效应模型估计了合并的优势比（OR）和 95%置信区间（CI），并使用 Review Manager 5.4 进行了荟萃分析。
总共纳入了 182 项研究中的 6 项，其中 1888 例（DR）和 2285 例（无 DR）为病例对照研究。荟萃分析结果显示，rs1501299 多态性与 DR 风险的 G 等位基因与 T 等位基因之间存在统计学显著关联（OR=0.84，95%CI=0.72-0.99， <0.05，I=23%，n=5 项研究）。此外，根据对照类型的亚组分析的汇总结果如下：DR 与糖尿病（DM）对照类型的 G 等位基因与 T 等位基因之间存在统计学显著关联：OR=0.81，95%CI=0.67-0.97， <0.05，I=27%，n=4 项研究；GG 与 GT：OR=0.72，95%CI=0.53-0.98， <0.05，I=49%，n=4 项研究；GG 与（GT+TT）：OR=0.73，95%CI=0.55-0.96， <0.05，I=44%，n=4 项研究。rs2241766 多态性与 DR 风险之间无显著关联。
目前的荟萃分析支持 ADIPOQ 基因的 rs1501299 多态性与糖尿病患者 DR 风险之间的关联。
