Department of Endocrinology, Taihe Hospital, Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan 442000, China.
Department of Radiology, Suizhou Hospital, Hubei University of Medicine, Suizhou Central Hospital, Suizhou 441300, China.
Aging (Albany NY). 2021 Feb 1;13(4):5136-5149. doi: 10.18632/aging.202433.
A close association between peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) and the development of diabetic retinopathy (DR) has been previously suggested. Herein, a meta-analysis was conducted to explore the association between polymorphisms and DR risk by performing a systematic search and quantitative analysis. Overall, fourteen articles involving 10,527 subjects were included. The pooled results did not reveal an association between rs1801282 C/G and DR susceptibility in the overall population (e.g., the dominant model: CG+GG vs. CC, OR=0.85, 95% CI=0.69-1.06, P=0.15, I=62.9%). Furthermore, heterogeneity tests, cumulative analyses, sensitivity analyses, and publication bias analyses were conducted and showed that the results were robust. Similarly, race-based subgroup analyses and other subgroup analyses did not reveal an association between the rs1801282 C/G and DR susceptibility. In addition, no significant association was observed between rs3856806 C/T polymorphism and DR risk (e.g., the dominant model: CT+TT vs. CC, OR=1.12, 95%CI=0.91-1.37, P=0.28, I=27.0%). Overall, based on the current sample size and the level of evidence presented in the study, the results suggest that gene polymorphisms are not associated with DR risk.
先前有研究表明，过氧化物酶体增殖物激活受体-γ2（PPAR-γ2）与糖尿病视网膜病变（DR）的发生密切相关。本研究通过系统检索和定量分析，进行荟萃分析以探讨基因多态性与 DR 风险之间的相关性。总体而言，纳入了 14 篇涉及 10527 例受试者的文章。汇总结果显示，rs1801282 C/G 多态性与总体人群的 DR 易感性之间无相关性（例如，显性模型：CG+GG 与 CC，OR=0.85，95%CI=0.69-1.06，P=0.15，I=62.9%）。此外，还进行了异质性检验、累积分析、敏感性分析和发表偏倚分析，结果均稳健。同样，基于种族的亚组分析和其他亚组分析也未显示 rs1801282 C/G 与 DR 易感性之间存在相关性。此外，rs3856806 C/T 多态性与 DR 风险之间也无显著相关性（例如，显性模型：CT+TT 与 CC，OR=1.12，95%CI=0.91-1.37，P=0.28，I=27.0%）。综上所述，基于当前样本量和研究中呈现的证据水平，结果表明基因多态性与 DR 风险无关。
