Preventive Medicine and Public Health Physician, Ministry of Health, Abha 62515, Saudi Arabia.
Community Medicine Consultant, Ministry of Health, Abha 62515, Saudi Arabia.
Medicina (Kaunas). 2024 Aug 19;60(8):1344. doi: 10.3390/medicina60081344.
The frequency of multidrug-resistant Klebsiella pneumoniae (MDRKP) has dramatically increased worldwide in recent decades, posing an urgent threat to public health. The aim of this study was to assess the extent of in the Aseer region and explore the corresponding antimicrobial resistance profile over the last ten years. A record-based retrospective study was conducted in a tertiary hospital during the period of 2013 to 2022. The study targeted laboratory samples taken from patients admitted to the hospital and sent for culturing. We included only samples taken from the patient and confirmed by the lab. Data were extracted using a pre-structured data extraction sheet to avoid data-collection bias and confirm the inter-rater precision. Statistical Package for Social Sciences (SPSS) version 26 was employed for statistical analysis. All relationships were tested using Pearson X test for categorical data or chi-square for linear trend for resistance rate over years. : We obtained 3921 samples of isolated out of 28,420 bacterial samples. The isolation rate began at 11.3% in 2013, decreased to 6.1% in 2016, and then increased to a peak of 16.3% in 2021, before slightly decreasing to 12.8% in 2022. In total, 23.7% of samples were identified in urine samples, 19% in sputum samples, 14% in wound samples, and 11.7% in blood samples. The overall antibiotic resistance rate of from 2013 to 2022 showed a significant increase, particularly during 2020 and 2021, before decreasing again in 2022. The resistance rate decreased from 22.2% in 2013 to 18.6% in 2016 and increased to 54.6% and 56.4% during 2020 and 2021, respectively ( = 0.039) We observed a significant shift in resistance for some antibiotics during the study period, highlighting the urgent need for enhanced antimicrobial stewardship and infection-control measures.
近年来，全球范围内多药耐药肺炎克雷伯菌（MDRKP）的频率显著增加，对公共卫生构成了紧迫威胁。本研究旨在评估过去十年阿西尔地区的流行程度，并探讨相应的抗生素耐药谱。
本研究采用回顾性记录研究方法，在 2013 年至 2022 年期间在一家三级医院进行。研究对象为医院收治并送检培养的患者的实验室样本。我们只纳入了实验室确认的患者样本。使用预先设计的数据提取表提取数据，以避免数据收集偏倚并确认组内一致性。采用统计软件包（SPSS）版本 26 进行统计分析。对于分类数据，采用 Pearson X 检验检验所有关系，对于线性趋势检验，采用卡方检验检验耐药率随年份的变化。
我们从 28420 个细菌样本中获得了 3921 个分离的肺炎克雷伯菌样本。2013 年的分离率为 11.3%，2016 年降至 6.1%，2021 年达到 16.3%的峰值，随后在 2022 年略有下降至 12.8%。总的来说，尿液样本中 23.7%的样本、痰液样本中 19%的样本、伤口样本中 14%的样本和血液样本中 11.7%的样本鉴定为肺炎克雷伯菌。2013 年至 2022 年，肺炎克雷伯菌的总体抗生素耐药率呈显著上升趋势，特别是在 2020 年和 2021 年，然后在 2022 年再次下降。2013 年的耐药率为 22.2%，2016 年降至 18.6%，2020 年和 2021 年分别上升至 54.6%和 56.4%（=0.039）。我们观察到研究期间一些抗生素的耐药性发生了显著变化，这突出表明迫切需要加强抗菌药物管理和感染控制措施。
