Cegolon Luca, Larese Filon Francesca
Department of Medical, Surgical & Health Sciences, University of Trieste, 34128 Trieste, Italy.
Public Health Department, University Health Agency Giuliano-Isontina (ASUGI), 34148 Trieste, Italy.
Life (Basel). 2024 Jul 23;14(8):916. doi: 10.3390/life14080916.
: Direct skin contact with items containing lanolin can induce sensitization and development of contact dermatitis (CD). This multi-centric study investigated prevalence of lanolin sensitization among 30,269 outpatients from North-Eastern Italy patch tested during 1997-2021. : European baseline and extended Triveneto series were applied on the upper part of patients' back and removed after 48 h. Risk factors for lanolin sensitization were investigated by multiple logistic regression analysis, reporting adjusted odds ratios (aOR) with 95% confidence interval (95%CI). . Overall lanolin patch test positive ratio (PTPR) was 1.64% (=501/30,629), with variability over time and by research center. The body area most frequently affected by CD were hands (36.32%), followed by face (19.52%) and legs (8.09%), with a lanolin PTPR of 1.68%, 1.37% and 3.07%, respectively. Prevalence of occupational CD was 8.24%, and 1.83% patients with occupational CD patch tested positive against lanolin. Lanolin sensitization was significantly higher in males (aOR = 1.34; 95%CI: 1.08; 1.65) and among patients with leg CD aged 49-60 years (aOR = 2.34; 95%CI: 1.20; 4.57) or older than 60 (aOR = 4.21; 95%CI: 2.59; 6.85). Sub-group analysis confirmed the significantly higher sensitization rate of older patients with leg CD, with much stronger effect size in females 61+ years old (aOR = 5.33; 95%CI 2.87; 9.89) than males in the same age group (aOR = 2.92; 95%CI: 1.34; 6.39). Moreover, female house painters were more likely to test positive to lanolin. : The variability of lanolin PTPR over time and by research center endorsed the ongoing debate on the relevance of the respective skin reaction. Clinicians assessing patients with dermatitis should collect information on potential risk factors for lanolin sensitization, particularly use of skin care products containing the hapten. Occupational exposure to lanolin-containing varnishes should also be considered.
皮肤直接接触含有羊毛脂的物品可引发致敏反应并导致接触性皮炎（CD）的发生。这项多中心研究调查了1997年至2021年间在意大利东北部接受斑贴试验的30269名门诊患者中羊毛脂致敏的患病率。欧洲基线和扩展的特里维内托系列斑贴试验应用于患者背部上方，48小时后去除。通过多因素逻辑回归分析研究羊毛脂致敏的危险因素，报告调整后的比值比（aOR）及95%置信区间（95%CI）。总体羊毛脂斑贴试验阳性率（PTPR）为1.64%（=501/30629），随时间和研究中心而变化。CD最常累及的身体部位是手部（36.32%），其次是面部（19.52%）和腿部（8.09%），羊毛脂PTPR分别为1.68%、1.37%和3.07%。职业性CD的患病率为8.24%，职业性CD患者中1.83%的斑贴试验对羊毛脂呈阳性。男性的羊毛脂致敏率显著更高（aOR = 其1.34；95%CI：1.08；1.65），49至60岁腿部患有CD的患者（aOR = 2.34；95%CI：1.20；4.57）或60岁以上患者（aOR = 4.21；95%CI：2.59；6.85）中也是如此。亚组分析证实，腿部患有CD的老年患者致敏率显著更高，61岁及以上女性的效应量比同年龄组男性更强（aOR = 5.33；95%CI 2.87；9.89）（aOR = 2.92；95%CI：1.34；6.39）。此外，女性房屋油漆工对羊毛脂检测呈阳性的可能性更大。羊毛脂PTPR随时间和研究中心的变化支持了关于相应皮肤反应相关性的持续争论。评估皮炎患者的临床医生应收集有关羊毛脂致敏潜在危险因素的信息，特别是含有该半抗原的护肤品的使用情况。还应考虑职业性接触含羊毛脂的清漆。
