Plećaš Doris, Gotovac Đogaš Vesna, Polašek Ozren, Škunca Herman Jelena
University of Split School of Medicine, 21000 Split, Croatia.
University of Split School of Mathematics, 21000 Split, Croatia.
Life (Basel). 2024 Jul 24;14(8):929. doi: 10.3390/life14080929.
The aim of this study was to explore retinal vasculature asymmetry (ReVA) patterns in subjects from the islands of Vis and Korcula and the city of Split, Croatia. Asymmetry estimates were based on topographic image analysis of non-mydriatic retinal fundus photographs and compared with nine ophthalmic measurements, three Doppler-based pressure indices and eight frequencies of audiometry. ReVA was also correlated to the genomic runs of homozygosity (ROHs) and used in a Cox regression survival model, where we adjusted for the effects of sex, age and comorbidity. In 1873 subjects, ReVA estimates were significantly correlated with most ophthalmic asymmetry measures, less strongly with the ankle-brachial pressure index and only modestly with higher-amplitude audiometry asymmetries (lowest = 0.020). ReVA was significantly correlated with the number of ROHs (r = 0.229, < 0.001) but less strongly with the ROH length (r = 0.101, < 0.001). The overlap of asymmetries was low, with only 107 subjects (5.7% of the total sample) who had two or more instances in which they were among the top 10%. Multiple asymmetries did not affect survival (HR = 0.74, 95% confidence intervals 0.45-1.22). Retinal vasculature asymmetry is a poor predictor of asymmetry elsewhere in the body. Despite its existence and apparent association with comorbidities, the observed extent of retinal vasculature asymmetry did not affect the lifespan in this population.
本研究旨在探究克罗地亚维斯岛、科尔丘拉岛以及斯普利特市居民的视网膜血管不对称性（ReVA）模式。不对称性评估基于非散瞳视网膜眼底照片的地形图分析，并与九项眼科测量指标、三项基于多普勒的压力指数以及八项听力测定频率进行比较。ReVA还与纯合子连续区域（ROHs）相关，并用于Cox回归生存模型，在此模型中我们对性别、年龄和合并症的影响进行了校正。在1873名受试者中，ReVA评估与大多数眼科不对称测量指标显著相关，与踝臂压力指数的相关性较弱，与高振幅听力测定不对称性的相关性仅为中等程度（最低为0.020）。ReVA与ROHs数量显著相关（r = 0.229，P < 0.001），但与ROH长度的相关性较弱（r = 0.101，P < 0.001）。不对称性的重叠程度较低，只有107名受试者（占总样本的5.7%）在两个或更多实例中处于前10%。多种不对称性并不影响生存（风险比 = 0.74，95%置信区间为0.45 - 1.22）。视网膜血管不对称性对身体其他部位的不对称性预测能力较差。尽管其存在且与合并症明显相关，但在该人群中观察到的视网膜血管不对称程度并未影响寿命。
