Lassola Sergio, Cundari Francesco, Marini Giuseppe, Corradi Francesco, De Rosa Silvia
Department of Anesthesia and Intensive Care, Santa Chiara Hospital, 38122 Trento, Italy.
Department of Surgical, Medical, Molecular Pathology and Critical Care Medicine, University of Pisa, 56126 Pisa, Italy.
Life (Basel). 2024 Aug 13;14(8):1005. doi: 10.3390/life14081005.
Acute kidney injury following trauma impacts patient recovery critically, necessitating an integrated approach to emergency care and nephrology. This review aims to provide a comprehensive understanding of trauma-induced nephropathy, highlighting recent advancements in pathophysiological insights, diagnostic techniques, and strategic interventions. Our key findings emphasize the role of biomarkers, like Neutrophil Gelatinase-Associated Lipocalin and Liver Fatty Acid-Binding Protein, and imaging techniques, such as contrast-enhanced ultrasound, in early AKI detection. Preventive strategies, including aggressive fluid resuscitation, avoidance of nephrotoxic agents, and hemodynamic optimization, are essential for mitigating AKI progression. Integrating these approaches into trauma care frameworks aims to enhance patient outcomes and set a foundation for future research and clinical improvements.
创伤后急性肾损伤严重影响患者康复,因此需要采取综合方法进行急诊护理和肾病治疗。本综述旨在全面了解创伤性肾病,重点介绍病理生理学见解、诊断技术和战略干预方面的最新进展。我们的主要发现强调了生物标志物(如中性粒细胞明胶酶相关脂质运载蛋白和肝脏脂肪酸结合蛋白)以及成像技术(如超声造影)在急性肾损伤早期检测中的作用。预防策略,包括积极的液体复苏、避免使用肾毒性药物和血流动力学优化,对于减轻急性肾损伤进展至关重要。将这些方法整合到创伤护理框架中旨在改善患者预后,并为未来的研究和临床改进奠定基础。