Kurt-Schwabe-Institut für Mess- und Sensortechnik Meinsberg e.V., 04736 Waldheim, Germany.
Leibniz Institute for Solid State and Material Research Dresden, 01069 Dresden, Germany.
Molecules. 2024 Aug 9;29(16):3770. doi: 10.3390/molecules29163770.
A ZnO-Graphene oxide nanocomposite (Z-G) was prepared in order to exploit the biomedical features of each component in a single anticancer material. This was achieved by means of an environmentally friendly synthesis, taking place at a low temperature and without the involvement of toxic reagents. The product was physicochemically characterized. The ZnO-to-GO ratio was determined through thermogravimetric analysis, while scanning electron microscopy and transmission electron microscopy were used to provide insight into the morphology of the nanocomposite. Using energy-dispersive X-ray spectroscopy, it was possible to confirm that the graphene flakes were homogeneously coated with ZnO. The crystallite size of the ZnO nanoparticles in the new composite was determined using X-ray powder diffraction. The capacity of Z-G to enhance the toxicity of the anticancer drug Paclitaxel towards breast cancer cells was assessed via a cell viability study, showing the remarkable anticancer activity of the obtained system. Such results support the potential use of Z-G as an anticancer agent in combination with a common chemotherapeutic like Paclitaxel, leading to new chemotherapeutic formulations.
为了在单一的抗癌材料中利用各组分的生物医学特性，制备了氧化锌-氧化石墨烯纳米复合材料（Z-G）。该复合材料通过在低温下且不使用有毒试剂的环保合成法来制备。对产物进行了物理化学特性分析。通过热重分析确定了 ZnO 与 GO 的比例，而扫描电子显微镜和透射电子显微镜则用于深入了解纳米复合材料的形态。通过能谱分析，证实了石墨烯片均匀地包覆了 ZnO。利用 X 射线粉末衍射法确定了新复合材料中 ZnO 纳米粒子的晶粒尺寸。通过细胞活力研究评估了 Z-G 增强抗癌药物紫杉醇对乳腺癌细胞毒性的能力，结果表明所得到的体系具有显著的抗癌活性。这些结果支持将 Z-G 用作抗癌剂与紫杉醇等常见化疗药物联合使用，从而产生新的化疗制剂。
