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一种氧化锌/姜黄素纳米复合材料的简便一锅水热合成法，其对乳腺癌细胞具有增强的毒性活性。

Facile one-pot hydrothermal synthesis of a zinc oxide/curcumin nanocomposite with enhanced toxic activity against breast cancer cells.

作者信息

Madeo Lorenzo Francesco, Schirmer Christine, Cirillo Giuseppe, Froeschke Samuel, Hantusch Martin, Curcio Manuela, Nicoletta Fiore Pasquale, Büchner Bernd, Mertig Michael, Hampel Silke

机构信息

Leibniz Institute for Solid State and Materials Research Dresden Dresden 01069 Germany

Kurt-Schwabe-Institut für Mess- und Sensortechnik Meinsberg e.V. Kurt-Schwabe-Straße 4 Waldheim 04736 Germany.

出版信息

RSC Adv. 2023 Sep 11;13(39):27180-27189. doi: 10.1039/d3ra05176e. eCollection 2023 Sep 8.

DOI:10.1039/d3ra05176e
PMID:37701282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10493854/
Abstract

Zinc oxide/Curcumin (Zn(CUR)O) nanocomposites were prepared hydrothermal treatment of Zn(NO) in the presence of hexamethylenetetramine as a stabilizing agent and CUR as a bioactive element. Three ZnO : CUR ratios were investigated, namely 57 : 43 (Zn(CUR)O-A), 60 : 40 (Zn(CUR)O-B) and 81 : 19 (Zn(CUR)O-C), as assessed by thermogravimetric analyses, with an average hydrodynamic diameter of nanoaggregates in the range of 223 to 361 nm. The interaction of CUR with ZnO hydroxyl and ketoenol groups (as proved by X-ray photoelectron spectroscopy analyses) was found to significantly modify the key properties of ZnO nanoparticles with the obtainment of a bilobed shape (as shown by scanning electron microscopy), and influenced the growth process of the composite nanoparticles as indicated by the varying particle sizes determined by powder X-ray diffraction. The efficacy of Zn(CUR)O as anticancer agents was evaluated on MCF-7 and MDA-MB-231 cancer cells, obtaining a synergistic activity with a cell viability depending on the CUR amount within the nanocomposite. Finally, the determination of reactive oxygen species production in the presence of Zn(CUR)O was used as a preliminary evaluation of the mechanism of action of the nanocomposites.

摘要

通过在六亚甲基四胺作为稳定剂和姜黄素（CUR）作为生物活性元素存在的情况下对硝酸锌（Zn(NO)）进行水热处理，制备了氧化锌/姜黄素（Zn(CUR)O）纳米复合材料。通过热重分析研究了三种ZnO : CUR比例，即57 : 43（Zn(CUR)O-A）、60 : 40（Zn(CUR)O-B）和81 : 19（Zn(CUR)O-C），纳米聚集体的平均流体动力学直径在223至361nm范围内。发现CUR与ZnO的羟基和酮烯醇基团之间的相互作用（通过X射线光电子能谱分析证实）显著改变了ZnO纳米颗粒的关键性质，获得了双叶形状（如扫描电子显微镜所示），并且如粉末X射线衍射测定的不同粒径所示，影响了复合纳米颗粒的生长过程。在MCF-7和MDA-MB-231癌细胞上评估了Zn(CUR)O作为抗癌剂的功效，根据纳米复合材料中CUR的含量获得了具有细胞活力的协同活性。最后，在存在Zn(CUR)O的情况下测定活性氧的产生，作为对纳米复合材料作用机制的初步评估。

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