Li Qin, Yuan Dan, Liu Chong, Herington Faith, Yang Ke, Ge Haibo
Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China.
Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA.
Molecules. 2024 Aug 17;29(16):3899. doi: 10.3390/molecules29163899.
A metal-free and Selectfluor-mediated selective oxidation reaction of benzo[]isothiazol-3(2)-ones in aqueous media is presented. This novel strategy provides a facile, green, and efficient approach to access important benzo[]isothiazol-3(2)-one-1-oxides with excellent yields and high tolerance to various functional groups. Furthermore, the purification of benzoisothiazol-3-one-1-oxides does not rely on column chromatography. Moreover, the preparation of saccharine derivatives has been achieved through sequential, double oxidation reactions in a one-pot aqueous media.
本文报道了一种在水介质中无金属且由Selectfluor介导的苯并[ ]异噻唑-3(2)-酮的选择性氧化反应。这种新颖的策略提供了一种简便、绿色且高效的方法来制备重要的苯并[ ]异噻唑-3(2)-酮-1-氧化物，产率优异且对各种官能团具有高耐受性。此外，苯并异噻唑-3-酮-1-氧化物的纯化不依赖柱色谱法。而且，通过在一锅水介质中进行连续的双氧化反应实现了糖精衍生物的制备。
