CCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticides & Chemical Biology Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University (CCNU), 152 Luoyu Road, Wuhan, Hubei 430079, China.
HICI Digital Power Technology Co., Ltd, Wuhan, Hubei, China.
Chem Commun (Camb). 2023 May 23;59(42):6272-6285. doi: 10.1039/d3cc01238g.
The chemistry of cyclic sulfinic acid derivatives (sultines and cyclic sulfinamides) was underdeveloped for a long time due to their inaccessibility. Considering the importance of cyclic sulfinate esters and amides in the fields of chemistry, pharmaceutical science, and material science, synthesis strategies involving cyclic sulfinic acid derivatives have been paid more attention in recent years, and have been widely used in the synthesis of sulfur-containing compounds such as sulfoxides, sulfones, sulfinates and thioethers. Despite the impressive improvements that have been made in last twenty years with the new strategies, to date, no reviews have been published, to the best of our knowledge, dealing with the preparation of cyclic sulfinic acid derivatives. This review summarizes the latest advances in the development of new synthesis methods to access cyclic sulfinic acid derivatives in the last two decades. The synthetic strategies are reviewed by highlighting their product diversity, selectivity and applicability, and the mechanistic rationale is presented where possible. We wish to bring readers a comprehensive understanding of the state-of-play of cyclic sulfinic acid derivative formation and make a contribution to future research.
由于其难以获得，环状亚砜酸衍生物（亚砜和环状亚磺酰胺）的化学性质在很长一段时间内都没有得到发展。考虑到环状亚磺酸盐酯和酰胺在化学、药物科学和材料科学领域的重要性，近年来，涉及环状亚砜酸衍生物的合成策略受到了更多的关注，并已广泛应用于含硫化合物如亚砜、砜、亚磺酸盐和硫醚的合成中。尽管在过去的二十年中，随着新策略的出现，已经取得了令人瞩目的进展，但据我们所知，迄今为止，还没有发表过关于环状亚砜酸衍生物制备的综述。本文综述了过去二十年中开发新型合成方法来获得环状亚砜酸衍生物的最新进展。通过突出其产物多样性、选择性和适用性来综述合成策略，并尽可能提出其反应机理。我们希望读者能全面了解环状亚砜酸衍生物形成的最新进展，并为未来的研究做出贡献。
