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基于适体的生物传感器在食源性真菌毒素检测中的进展。

Advances in Aptamer-Based Biosensors for the Detection of Foodborne Mycotoxins.

机构信息

Chongqing Key Laboratory for New Chemical Materials of Shale Gas, College of Chemistry and Chemical Engineering, Yangtze Normal University, Fuling, Chongqing 408100, China.

School of Cable Engineering, Henan Institute of Technology, Xinxiang 453003, China.

出版信息

Molecules. 2024 Aug 22;29(16):3974. doi: 10.3390/molecules29163974.

Abstract

Foodborne mycotoxins (FBMTs) are toxins produced by food itself or during processing and transportation that pose an enormous threat to public health security. However, traditional instrumental and chemical methods for detecting toxins have shortcomings, such as high operational difficulty, time consumption, and high cost, that limit their large-scale applications. In recent years, aptamer-based biosensors have become a new tool for food safety risk assessment and monitoring due to their high affinity, good specificity, and fast response. In this review, we focus on the progress of single-mode and dual-mode aptasensors in basic research and device applications over recent years. Furthermore, we also point out some problems in the current detection strategies, with the aim of stimulating future toxin detection systems for a transition toward ease of operation and rapid detection.

摘要

食源性真菌毒素(FBMTs)是由食物本身或在加工和运输过程中产生的毒素,对公共卫生安全构成巨大威胁。然而,传统的仪器和化学方法检测毒素存在操作难度大、耗时耗力、成本高等缺点,限制了其大规模应用。近年来,基于适配体的生物传感器因其高亲和力、良好的特异性和快速响应而成为食品安全风险评估和监测的新工具。本文主要综述了近年来单模态和双模态适配体传感器在基础研究和器件应用方面的进展,并指出了目前检测策略中存在的一些问题,以期为未来的毒素检测系统向操作简便、快速检测的方向发展提供启示。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9f2/11356850/1aba85a21203/molecules-29-03974-sch001.jpg

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