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使用LuAG:Ce晶体探测器对放射治疗肿瘤过程中X射线束均匀性的研究。

Investigation of X-rays Beams Uniformity in Radiotherapeutic Tumor Treatment Procedure Using LuAG:Ce Crystal Detectors.

作者信息

Witkiewicz-Łukaszek Sandra, Winiecki Janusz, Michalska Paulina, Jakubowski Seweryn, Sidletskiy Oleg, Zorenko Yuriy

机构信息

Faculty of Physics, Kazimierz Wielki University in Bydgoszcz, Powstańców Wielkopolskich Street 2, 85-090 Bydgoszcz, Poland.

Franciszek Łukaszyk Oncology Center, Medical Physics Department, dr Izabeli Romanowskiej Street 2, 85-796 Bydgoszcz, Poland.

出版信息

Materials (Basel). 2024 Aug 13;17(16):4016. doi: 10.3390/ma17164016.

DOI:10.3390/ma17164016
PMID:39203194
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11356305/
Abstract

In this study, Ce-doped LuAlO garnet (LuAG) crystal detectors, with a density of ρ = 6 g/cm and an effective atomic number Z = 62, are proposed as promising materials for radiotherapy applications. This type of detector demonstrates excellent uniformity of structural and optical properties, high thermoluminescence (TL) light yield, optimal position of main TL glow peaks at temperatures around 245-295 °C, and high radiation stability. The set of TL detectors made from LuAG:Ce single crystal was used to evaluate the uniformity of dose and energy spectra of X-ray radiation from a clinical accelerator with 6 MV and 15 MV beams at the Department of Medical Physics, Oncology Center in Bydgoszcz, Poland, and γ-rays from a Co source at the National Institute of Oncology in Warsaw. The LuAG:Ce crystal detectors demonstrated highly promising results for registering X-ray radiation from accelerators with both 6 MV and 15 MV electron beams, as well as γ-rays from a Co source with energies of 1.17 and 1.33 MeV.

摘要

在本研究中，提出将密度ρ = 6 g/cm³且有效原子序数Z = 62的铈掺杂铝酸镥（LuAG）晶体探测器作为放射治疗应用中有前景的材料。这种类型的探测器展现出优异的结构和光学性能均匀性、高热释光（TL）发光产额、主TL发光峰在245 - 295 °C左右温度下的最佳位置以及高辐射稳定性。由LuAG:Ce单晶制成的一组TL探测器被用于评估波兰比得哥什肿瘤中心医学物理部6 MV和15 MV束流的临床加速器产生的X射线辐射以及华沙国家肿瘤研究所钴源产生的γ射线的剂量和能谱均匀性。LuAG:Ce晶体探测器在记录来自6 MV和15 MV电子束加速器的X射线辐射以及能量为1.17和1.33 MeV的钴源产生的γ射线方面展现出非常有前景的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9af9/11356305/816c88257349/materials-17-04016-g012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9af9/11356305/83b5f27782d9/materials-17-04016-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9af9/11356305/57ea1d2c1cff/materials-17-04016-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9af9/11356305/411811651d0a/materials-17-04016-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9af9/11356305/f825be05ad9c/materials-17-04016-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9af9/11356305/d5e2c7c847f1/materials-17-04016-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9af9/11356305/816c88257349/materials-17-04016-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9af9/11356305/9110fe37acf0/materials-17-04016-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9af9/11356305/d9b0d9cc7ce9/materials-17-04016-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9af9/11356305/ed19bfac57c7/materials-17-04016-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9af9/11356305/b19522814246/materials-17-04016-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9af9/11356305/83b5f27782d9/materials-17-04016-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9af9/11356305/57ea1d2c1cff/materials-17-04016-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9af9/11356305/411811651d0a/materials-17-04016-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9af9/11356305/f825be05ad9c/materials-17-04016-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9af9/11356305/14c0ad8bfd43/materials-17-04016-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9af9/11356305/124e6612d47f/materials-17-04016-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9af9/11356305/d5e2c7c847f1/materials-17-04016-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9af9/11356305/816c88257349/materials-17-04016-g012.jpg

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本文引用的文献

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Materials (Basel). 2022 Nov 22;15(23):8288. doi: 10.3390/ma15238288.
2
Basic Characteristics of Dose Distributions of Photons Beam for Radiotherapeutic Applications Using YAG:Ce Crystal Detectors.使用YAG:Ce晶体探测器的放射治疗应用中光子束剂量分布的基本特征
Materials (Basel). 2022 Nov 7;15(21):7861. doi: 10.3390/ma15217861.
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Boron neutron capture therapy (BNCT): a unique role in radiotherapy with a view to entering the accelerator-based BNCT era.
硼中子俘获治疗（BNCT）：放疗中的独特角色，展望进入基于加速器的 BNCT 时代。
Int J Clin Oncol. 2020 Jan;25(1):43-50. doi: 10.1007/s10147-019-01480-4. Epub 2019 Jun 5.
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High-resolution optical spectroscopy of YAG:Nd: A test for structural and distribution models.钇铝石榴石：钕的高分辨率光学光谱学：结构与分布模型的一项测试
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